| Identification | Back Directory | [Name]
L-Serine, L-seryl-L-phenylalanyl-L-histidyl-L-glutaminyl-L-phenylalanyl-L-alanyl-L-arginyl-L-alanyl-L-threonyl-L-leucyl-L-alanyl- | [CAS]
329004-38-8 | [Synonyms]
L-Serine, L-seryl-L-phenylalanyl-L-histidyl-L-glutaminyl-L-phenylalanyl-L-alanyl-L-arginyl-L-alanyl-L-threonyl-L-leucyl-L-alanyl- | [Molecular Formula]
C60H90N18O17 | [MOL File]
329004-38-8.mol | [Molecular Weight]
1335.47 |
| Chemical Properties | Back Directory | [density ]
1.47±0.1 g/cm3(Predicted) | [form ]
Solid | [pka]
3.02±0.10(Predicted) | [color ]
White to off-white | [Sequence]
Ser-Phe-His-Gln-Phe-Ala-Arg-Ala-Thr-Leu-Ala-Ser |
| Hazard Information | Back Directory | [Uses]
HAP-1 is a synovial-targeted transduction peptide. HAP-1 facilitates specific internalization of protein complexes into human and rabbit synovial cells. HAP-1 fused to an antimicrobial peptide, (KLAK)2, to generate a proapoptotic peptide DP2[1]. | [References]
[1] Mi Z, et al. Identification of a synovial fibroblast-specific protein transduction domain for delivery of apoptotic agents to hyperplastic synovium. Mol Ther. 2003 Aug;8(2):295-305. DOI:10.1016/s1525-0016(03)00181-3 |
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