| Identification | Back Directory | [Name]
ETHANOL, 2-[2-[4-(5-OXIDODIBENZO[B,F][1,4]THIAZEPIN-11-YL)-1-PIPERAZINYL]ETHOXY]- ,DIHYDROCHLORIDE | [CAS]
329218-11-3 | [Synonyms]
Quetiapine EP Impurity S HCl Salt
Quetiapine S-oxide dihydrochloride
Quetiapine sulfoxide (dihydrochloride)
Quetiapine EP Impurity S DiHCl (Quetiapine Sulfoxide DiHCl)
QUETIAPINE SULFOXIDE DIHYDROCHLORIDE; QUETIAPINE S-OXIDE DIHYDROCHLORIDE
ETHANOL, 2-[2-[4-(5-OXIDODIBENZO[B,F][1,4]THIAZEPIN-11-YL)-1-PIPERAZINYL]ETHOXY]- ,DIHYDROCHLORIDE | [Molecular Formula]
C21H28Cl2N3O3S- | [MOL File]
329218-11-3.mol | [Molecular Weight]
473.436 |
| Hazard Information | Back Directory | [Uses]
Quetiapine sulfoxide dihydrochloride (Quetiapine S-oxide dihydrochloride) is a main metabolite of Quetiapinem. Quetiapine is a second-generation antipsychotic[1]. Quetiapine is a 5-HT receptors agonist and a dopamine receptor antagonist[2]. | [in vivo]
The Cmax value (mean±SD) is estimated for Quetiapine sulfoxide (77.3±32.4 ng/mL). The AUClast value is estimated for Quetiapine sulfoxide (1,286±458 ng?h/mL). For Quetiapine sulfoxide, metabolic ratio decreases with time, from 119% on average 2 hours after dosing to 30% on average 72 hours after dosing[1]. | [storage]
Store at -20°C | [References]
[1] Remmerie B, et al. Comparison of Capillary and Venous Drug Concentrations After Administration of a Single Dose of Risperidone, Paliperidone, Quetiapine, Olanzapine, or Aripiprazole. Clin Pharmacol Drug Dev. 2016 Nov;5(6):528-537. DOI:10.1002/cpdd.290
[2] Cross AJ, et al. Quetiapine and its metabolite norquetiapine: translation from in vitro pharmacology to in vivo efficacy in rodent models. Br J Pharmacol. 2016 Jan;173(1):155-66. DOI:10.1111/bph.13346 |
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