| Identification | Back Directory | [Name]
Sanggenol L | [CAS]
329319-20-2 | [Synonyms]
Sanggenol L
2-(2,4-Dihydroxyphenyl)-2,3-dihydro-5-hydroxy-8-methyl-8-(4-methyl-3-pentenyl)-4H,8H-benzo[1,2-b:3,4-b']dipyran-4-one
4H,8H-Benzo[1,2-b:3,4-b']dipyran-4-one, 2-(2,4-dihydroxyphenyl)-2,3-dihydro-5-hydroxy-8-methyl-8-(4-methyl-3-pentenyl)- (9CI) | [Molecular Formula]
C25H26O6 | [MDL Number]
MFCD32901213 | [MOL File]
329319-20-2.mol | [Molecular Weight]
422.47 |
| Chemical Properties | Back Directory | [Boiling point ]
662.2±55.0 °C(Predicted) | [density ]
1.280±0.06 g/cm3(Predicted) | [solubility ]
Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc. | [form ]
Powder | [pka]
7.50±0.60(Predicted) | [color ]
Light yellow to yellow |
| Hazard Information | Back Directory | [Uses]
Sanggenol L induces caspase-dependent and caspase-independent apoptosis in melanoma skin cancer cells[1]. Sanggenol L induces of apoptosis via suppression of PI3K/Akt/mTOR signaling and cell cycle arrest via activation of p53 in p | [Definition]
ChEBI: Sanggenol L is an extended flavonoid. | [target]
p65 | NF-kB | IkB | c-Myc | Caspase | IKK | [References]
[1] Won YS, Seo KI. Sanggenol L promotes apoptotic cell death in melanoma skin cancer cells through activation of caspase cascades and apoptosis-inducing factor.?Food Chem Toxicol. 2020;138:111221. DOI:10.1016/j.fct.2020.111221
[2] Won YS, Seo KI. Sanggenol L Induces Apoptosis and Cell Cycle Arrest via Activation of p53 and Suppression of PI3K/Akt/mTOR Signaling in Human Prostate Cancer Cells.?Nutrients. 2020;12(2):488. Published 2020 Feb 14. DOI:10.3390/nu12020488 |
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