| Identification | Back Directory | [Name]
sophoflavescenol | [CAS]
216450-65-6 | [Synonyms]
sophoflavescenol
3,7-Dihydroxy-2-(4-hydroxyphenyl)-5-methoxy-8-(3-methyl-2-butenyl)-4H-1-benzopyran-4-one
4H-1-Benzopyran-4-one, 3,7-dihydroxy-2-(4-hydroxyphenyl)-5-methoxy-8-(3-methyl-2-buten-1-yl)- | [Molecular Formula]
C21H20O6 | [MDL Number]
MFCD30534403 | [MOL File]
216450-65-6.mol | [Molecular Weight]
368.38 |
| Chemical Properties | Back Directory | [Melting point ]
273-275 °C | [Boiling point ]
631.8±55.0 °C(Predicted) | [density ]
1.359±0.06 g/cm3(Predicted) | [storage temp. ]
4°C, away from moisture and light | [solubility ]
Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc. | [form ]
powder | [pka]
7.03±0.40(Predicted) | [color ]
Yellow |
| Hazard Information | Back Directory | [Uses]
Sophoflavescenol is a potential cytotoxic agent against lung cancer A549 cells and colon cancer HCT116 cells. | [Synthesis]
7,8-(2,2-Dimethyl-2H-pyran)-5,4-dihydroxyflavonol (Sophorol, 12):(CH3)2SO4 (10.53 mmol, 1.0 mL) was added dropwise to a stirred solution of 11 (500 mg, 1.02 mmol) in NaOH (5% aqueous solution; 15 mL). The mixture was stirred at room temperature and mainta | [in vivo]
Sophoflavescenol exerts potent in?vivo?antitumor?activity?by tumor growth inhibition in the LLC tumor model as well as apoptotic?activity?by caspase-3 activation in HL-60 cells[1]. | [target]
Caspase | ROS | NF-kB | NO | BACE | PDE | [IC 50]
BACE1; AChE; BChE; PDE5 |
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