| Identification | Back Directory | [Name]
Urocortin II (mouse) | [CAS]
330648-32-3 | [Synonyms]
UROCORTIN II (MOUSE)
UCN II (MOUSE) TRIFLUOROACETATE
UROCORTIN II (MOUSE) TRIFLUOROACETATE
H-VAL-ILE-LEU-SER-LEU-ASP-VAL-PRO-ILE-GLY-LEU-LEU-ARG-ILE-LEU-LEU-GLU-GLN-ALA-ARG-TYR-LYS-ALA-ALA-ARG-ASN-GLN-ALA-ALA-THR-ASN-ALA-GLN-ILE-LEU-ALA-HIS-VAL-NH2 TRIFLUOROACETATE | [MDL Number]
MFCD09039228 |
| Chemical Properties | Back Directory | [storage temp. ]
-20°C | [form ]
Solid | [color ]
White to off-white | [biological source]
mouse | [Sequence]
Val-Ile-Leu-Ser-Leu-Asp-Val-Pro-Ile-Gly-Leu-Leu-Arg-Ile-Leu-Leu-Glu-Gln-Ala-Arg-Tyr-Lys-Ala-Ala-Arg-Asn-Gln-Ala-Ala-Thr-Asn-Ala-Gln-Ile-Leu-Ala-His-Val-NH2 |
| Hazard Information | Back Directory | [Uses]
Mouse urocortin II can be used for immunohistochemistry. | [Biochem/physiol Actions]
Urocortin II is a CRF-related neuropeptide having high affinity for CRF2 receptor. It stimulates protein kinase A through CRF2 receptor and increases the contractility in rabbit ventricular myocytes. It also facilitates pro-inflammatory effects in human intestinal cells through corticotropin-releasing hormone receptor 2α. | [in vivo]
Urocortin II, mouse (1-10 μg; icv and i.v.; Adult male Sprague-Dawley rats) induces the expression of Fos[2].
Urocortin II, mouse (1 μg; icv; Adult male Sprague-Dawley rats) is involved in central autonomic nervous system and appetite control[2].
| Animal Model: | Adult male Sprague-Dawley rats (250-300 g)[2] | | Dosage: | 1, 5, and 10 μg | | Administration: | Intracerebroventrical injection and intravenous injection; 1, 5, or 10 μg per animal in 2 μL of saline for i.c.v. injections or 200 μL for i.v. administration | | Result: | Induced Fos expression in a dose-dependent manner. |
| Animal Model: | Adult male Sprague-Dawley rats (250-300 g)[2] | | Dosage: | 1 μg | | Administration: | Intracerebroventrical injection | | Result: | Reduced food intake over the 12-h interval. |
| [IC 50]
CRFR2: 0.66 nM (Ki); CRFR1: ﹥100 nM (Ki) |
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