| Identification | Back Directory | [Name]
2-[(4-Acetylphenyl)azo]-2-(3,4-dihydro-3,3-diMethyl-1(2H)-
isoquinolinylidene)acetaMide | [CAS]
331001-62-8 | [Synonyms]
IQ 1; IQ1
IQ-1 - CAS 331001-62-8 - Calbiochem
2-[(4-Acetylphenyl)hydrazinylidene]-2-(3,3-dimethyl-4H-isoquinolin-1-yl)acetamide
2-[(4-Acetylphenyl)azo]-2-(3,4-dihydro-3,3-diMethyl-1(2H)-
isoquinolinylidene)acetaMide
2-[2-(4-Acetylphenyl)diazenyl]-2-(3,4-dihydro-3,3-diMethyl-1(2H)-isoquinolinylidene)-acetaMide
AcetaMide, 2-[2-(4-acetylphenyl)diazenyl]-2-(3,4-dihydro-3,3-diMethyl-1(2H)-isoquinolinylidene)- | [Molecular Formula]
C21H22N4O2 | [MDL Number]
MFCD00354369 | [MOL File]
331001-62-8.mol | [Molecular Weight]
362.42 |
| Chemical Properties | Back Directory | [Boiling point ]
591.2±50.0 °C(Predicted) | [density ]
1.23±0.1 g/cm3(Predicted) | [storage temp. ]
-20°C | [solubility ]
DMF: 30 mg/ml; DMSO: 25 mg/ml; Ethanol: 10 mg/ml | [form ]
powder | [pka]
15.71±0.50(Predicted) | [color ]
yellow to orange | [InChI]
1S/C21H22N4O2/c1-13(26)14-8-10-16(11-9-14)24-25-19(20(22)27)18-17-7-5-4-6-15(17)12-21(2,3)23-18/h4-11,23H,12H2,1-3H3,(H2,22,27)/b19-18+,25-24? | [InChIKey]
ZXSRRUROLCGTBS-ASEVQSCHSA-N | [SMILES]
CC(C1=CC=C(N=N/C(C(N)=O)=C2NC(C)(C)CC3=C/2C=CC=C3)C=C1)=O |
| Hazard Information | Back Directory | [Uses]
IQ 1 disrupts Wnt signaling. IQ-1 in conjunction with Wnt3a has been shown to be sufficient to maintain murine embryonic stem cell proliferation in the absence of serum. Binds to the PR72/PR130 subunit of protein phosphatase PP2A preventing β-catenin from switching co-activator usage from CBP to p300 leading to an increase in β-catenin/CBP-driven transcription at the expense of β-catenin/p300-driven transcription. | [Definition]
ChEBI: 2-[(4-acetylphenyl)hydrazinylidene]-2-(3,3-dimethyl-4H-isoquinolin-1-yl)acetamide is an aromatic ketone. | [Biological Activity]
IQ-1 enhances β-catenin/CBP interactions and blocks β-catenin/p300 driven transcriptionwhich enables mouse embryonic stem cells (ESCs) to be maintained in an undifferentiated pluripotent stateallowing expansion and self-renewal of mouse ESC populations. | [storage]
-20°C |
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