| Identification | More | [Name]
ETHYL 2-(3-OXO-2-PIPERAZINYL)ACETATE | [CAS]
33422-35-4 | [Synonyms]
(3-OXO-PIPERAZIN-2-YL)-ACETIC ACID ETHYL ESTER
AKOS BBB/039
AKOS BC-0605
BUTTPARK 32\06-70
ETHYL 2-(3-OXO-2-PIPERAZINYL)ACETATE
ETHYL 2-(3-OXOPIPERAZIN-2-YL)ACETATE
ETHYL (3-OXOPIPERAZIN-2-YL)ACETATE
TIMTEC-BB SBB010112
ETHYL 3-OXOPIPERAZINE-2-ACETATE
3-Oxo-2-piperazineacetic acid ethyl ester | [Molecular Formula]
C8H14N2O3 | [MDL Number]
MFCD00052897 | [Molecular Weight]
186.21 | [MOL File]
33422-35-4.mol |
| Chemical Properties | Back Directory | [Melting point ]
110-111°C | [Boiling point ]
360.6±27.0 °C(Predicted) | [density ]
1.101±0.06 g/cm3(Predicted) | [storage temp. ]
Keep in dark place,Sealed in dry,2-8°C | [pka]
15.06±0.40(Predicted) | [Appearance]
White to off-white Solid | [InChI]
InChI=1S/C8H14N2O3/c1-2-13-7(11)5-6-8(12)10-4-3-9-6/h6,9H,2-5H2,1H3,(H,10,12) | [InChIKey]
HNYRNJAZRKCHSC-UHFFFAOYSA-N | [SMILES]
N1CCNC(=O)C1CC(OCC)=O | [CAS DataBase Reference]
33422-35-4(CAS DataBase Reference) |
| Safety Data | Back Directory | [Hazard Codes ]
Xi | [Risk Statements ]
R36/37/38:Irritating to eyes, respiratory system and skin . | [Safety Statements ]
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection . | [Hazard Note ]
Irritant | [HazardClass ]
IRRITANT | [HS Code ]
2933599590 |
| Hazard Information | Back Directory | [Synthesis]
1. Ethylenediamine (1.17 mL, 17.42 mmol) and diethyl maleate (3 g, 17.42 mmol) were added to a 50 mL round bottom flask and dissolved in propanol (30 mL). 2. The reaction mixture was stirred at 55 °C for 16 h. 3. Upon completion of the reaction, the solvent was removed under reduced pressure by rotary evaporator. 4. The residue was placed in a vacuum drying chamber and The residue was dried to give the crude ethyl 2-(3-oxopiperazin-2-yl)acetate. 5. The crude product was used directly in the next step of the reaction without further purification. Yield: 3.4 g (quantitative yield). | [References]
[1] Patent: US2008/312231, 2008, A1. Location in patent: Page/Page column 40
[2] Journal of Heterocyclic Chemistry, 1993, vol. 30, # 1, p. 275 - 276
[3] Journal of Pharmaceutical Sciences, 1990, vol. 79, # 5, p. 447 - 452 |
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