Back to ChemicalBook Home--->CAS DataBase List--->141-78-6

141-78-6

141-78-6 Structure

141-78-6 Structure
IdentificationMore
[Name]

Ethyl acetate
[CAS]

141-78-6
[Synonyms]

ABSOLUTE ALCOHOL
ACETIC ACID ETHYL ESTER
ACETIC ESTER
ACETIC ETHER
AKOS BBS-00004223
ALCOHOL
ALCOHOL C2
ALCOHOL, DENATURED
ALCOHOL, REAGENT, DENATURED
BASIC ORGANIC RAW
DENATURED ALCOHOL
etanol
ETHANOL
ETHANOL-10
ETHANOL-100
ETHANOL-15
ETHANOL-150
ETHANOL-20
ETHANOL-200
ETHANOL-25
[EINECS(EC#)]

205-500-4
[Molecular Formula]

C4H8O2
[MDL Number]

MFCD00003568
[Molecular Weight]

88.11
[MOL File]

141-78-6.mol
Chemical PropertiesBack Directory
[Appearance]

Colorless liquid
[Appearance]

Ethyl acetate is a colorless liquid. Pleasant, fruity odor.
[Appearance]

Excipient.
[mp ]

−84 °C(lit.)
[bp ]

76.5-77.5 °C(lit.)
[density ]

0.902 g/mL at 25 °C(lit.)
[vapor density ]

3 (20 °C, vs air)
[vapor pressure ]

73 mm Hg ( 20 °C)
[FEMA ]

2414
[refractive index ]

n20/D 1.3720(lit.)
[Fp ]

26 °F
[storage temp. ]

2-8°C
[Stability:]

Stable. Incompatible with various plastics, strong oxidizing agents. Highly flammable. Vapour/air mixtures explosive. May be moisture sensitive.
[Water Solubility ]

80 g/L (20 ºC)
[Detection Methods]

GC
[Merck ]

14,3757
[BRN ]

506104
[CAS DataBase Reference]

141-78-6(CAS DataBase Reference)
[NIST Chemistry Reference]

Ethyl acetate(141-78-6)
[Storage Precautions]

Moisture sensitive
[EPA Substance Registry System]

141-78-6(EPA Substance)
Safety DataBack Directory
[Hazard Codes ]

F,Xi,Xn,T
[Risk Statements ]

R11:Highly Flammable.
R36:Irritating to the eyes.
R66:Repeated exposure may cause skin dryness or cracking.
R67:Vapors may cause drowsiness and dizziness.
R20/21/22:Harmful by inhalation, in contact with skin and if swallowed .
R10:Flammable.
R39/23/24/25:Toxic: danger of very serious irreversible effects through inhalation, in contact with skin and if swallowed .
R23/24/25:Toxic by inhalation, in contact with skin and if swallowed .
R68/20/21/22:Harmful: possible risk of irreversible effects through inhalation, in contact with skin and if swallowed .
[Safety Statements ]

S16:Keep away from sources of ignition-No smoking .
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S33:Take precautionary measures against static discharges .
S36/37:Wear suitable protective clothing and gloves .
S45:In case of accident or if you feel unwell, seek medical advice immediately (show label where possible) .
S7:Keep container tightly closed .
S25:Avoid contact with eyes .
[RIDADR ]

UN 1173 3/PG 2
[WGK Germany ]

1
[RTECS ]

AH5425000
[F ]

1
[HazardClass ]

3
[PackingGroup ]

II
[HS Code ]

29153100
[Safety Profile]

Potentially poisonous by ingestion. Toxicity depends upon alcohols in question, generally ethanol with methanol as a denaturant. A flammable liquid and dangerous fire hazard; can react vigorously with oxidzing materials. Moderate explosion hazard. See ETHANOL, METHYL ALCOHOL, and n-PROPYL ALCOHOL.
[Hazardous Substances Data]

141-78-6(Hazardous Substances Data)
Raw materials And Preparation ProductsBack Directory
[Raw materials]

Etanol-->Sulfuric acid -->Acetic acid glacial-->Potassium carbonate-->1-Butanol-->Calcium oxide-->Potassium Acetate-->ketene
[Preparation Products]

N-ETHYL 3-NITROBENZENESULFONAMIDE-->Methyl 4-bromo-3-nitrobenzoate-->ETHYL ISONICOTINOYLACETATE-->Sodium 1-heptanesulfonate-->D-glucose pentakis[3,4-dihydroxy-5-[(trihydroxy-3,4,5-benzoyl)oxy]benzoate] -->Ampicillin sodium-->Diphenyl N-cyanocarbonimidate-->4(1H)-Pyrimidinone, 2-methyl-(8CI,9CI)-->4-FLUOROBENZYL ISOCYANATE-->2-(2-FORMYL-PHENOXY)-PROPIONIC ACID-->N-METHOXYCARBONYLMALEIMIDE-->2-Amino-6-bromopyridine-->3-METHYL-4-PYRIDINECARBOXYLIC ACID-->N-BENZYL-6-CHLORO-N-METHYLPYRIDAZIN-3-AMINE-->polyurethane adhesive for dry laminating-->2-ISOCYANATO-4,6-DIMETHOXYPYRIMIDINE-->Methyl 3-bromo-4-methylbenzoate-->N-Acetylethylenediamine-->3-Hydroxypiperidine-->ETHYL PICOLINOYLACETATE-->N-Hexadecyltrimethylammonium chloride-->Boc-O-benzyl-L-tyrosine-->2-Acetylthiazole-->ALUMINUM DI(ISOPROPOXIDE)ACETOACETIC ESTER CHELATE-->Tea polyphenol-->2-(4-Ethoxyphenyl)-2-methylpropanol-->BOC-Glycine-->dry laminating adhesive AD-->adhesive No.1 for shrink packaging-->Triphenylsilanol-->granular adhesive PUA-->special adhesive JA-501 for laminating packaging materials-->special adhesive JA-502 for aluminum-plastics laminating tape-->Enoximone-->coating adhesive tiemao 102-->adhesive M-861 for polyolefin plastics-->self curing adhesive SL-B404-->wealant XY-2-->Water-proof adhesive-->adhesive JX-18-1
Hazard InformationBack Directory
[General Description]

A clear colorless liquid with a fruity odor. Flash point 24°F. Less dense than water. Vapors heavier than air.
[Reactivity Profile]

ETHYL ACETATE(141-78-6) is also sensitive to heat. On prolonged storage, materials containing similar functional groups have formed explosive peroxides. This chemical may ignite or explode with lithium aluminum hydride. ETHYL ACETATE(141-78-6) may also ignite with potassium tert-butoxide. ETHYL ACETATE(141-78-6) is incompatible with nitrates, strong alkalis and strong acids. ETHYL ACETATE(141-78-6) will attack some forms of plastics, rubber and coatings. ETHYL ACETATE(141-78-6) is incompatible with oxidizers such as hydrogen peroxide, nitric acid, perchloric acid and chromium trioxide. Violent reactions occur with chlorosulfonic acid. . SOCl2 reacts with esters, such as ETHYL ACETATE(141-78-6), forming toxic SO2 gas and water soluble/toxic acyl chlorides, catalyzed by Fe or Zn (Spagnuolo, C.J. et al. 1992. Chemical and Engineering News 70(22):2.).
[Air & Water Reactions]

Highly flammable. Slightly soluble in water. This chemical is slowly hydrolyzed by moisture.
[Hazard]

Toxic by inhalation and skin absorption; irritant to eyes and skin. Flammable, dangerous fire and explosion risk, flammable limits in air 2.2–9%. Questionable carcinogen.
[Health Hazard]

Headache, irritation of respiratory passages and eyes, dizziness and nausea, weakness, loss of consciousness.
[Potential Exposure]

This material is used as a solvent for nitrocellulose and lacquer. It is also used in making dyes,flavoring and perfumery, and in smokeless powder manufacture
[Fire Hazard]

HIGHLY FLAMMABLE: Will be easily ignited by heat, sparks or flames. Vapors may form explosive mixtures with air. Vapors may travel to source of ignition and flash back. Most vapors are heavier than air. They will spread along ground and collect in low or confined areas (sewers, basements, tanks). Vapor explosion hazard indoors, outdoors or in sewers. Runoff to sewer may create fire or explosion hazard. Containers may explode when heated. Many liquids are lighter than water.
[First aid]

If this chemical gets into the eyes, remove any contact lenses at once and irrigate immediately for at least 15 minutes, occasionally lifting upper and lower lids. Seek medical attention immediately. If this chemical contacts the skin, remove contaminated clothing and wash immediately with soap and water. Seek medical attention immediately. If this chemical has been inhaled, remove from exposure, begin rescue breathing (using universal precautions, including resuscitation mask) if breathing has stopped and CPR if heart action has stopped. Transfer promptly to a medical facility. When this chemical has been swallowed, get medical attention. Give large quantities of water and induce vomiting. Do not make an unconscious person vomit.
[Shipping]

UN1173 Ethyl acetate, Hazard Class: 3; Labels: 3-Flammable liquid.
[Incompatibilities]

May form explosive mixture with air. Heating may cause violent combustion or explosion. Incompatible with strong acids; strong alkalies; nitrates, strong oxidizers; chlorosulfonic acid; lithium aluminum hydride; oleum will hydrolyze on standing forming acetic acid and ethyl alcohol. This reaction is greatly accelerated by alkalies. Decomposes under influence of UV light, bases, and acids. Attacks aluminum and plastics.
[Waste Disposal]

Dissolve or mix the material with a combustible solvent and burn in a chemical incinerator equipped with an afterburner and scrubber. All federal, state, and local environmental regulations must be observed. Consult with environmental regulatory agencies for guidance on acceptable disposal practices. Generators of waste containing this contaminant (≧100 kg/ mo) must conform with EPA regulations governing storage, transportation, treatment, and waste disposal.
Material Safety Data Sheet(MSDS)Back Directory
[msds information]

ethyl acetate(141-78-6).msds
Questions And AnswerBack Directory
[Introduction]

Ethyl Acetate is an organic ester compound with a molecular formula of C4H8O2 (commonly abbreviated as EtOAc or EA), appears as a colorless liquid. It is highly miscible with all common organic solvents (alcohols, ketones, glycols, esters), which make it a common solvent for cleaning, paint removal and coatings.
Ethyl acetate is found in alcoholic beverages, cereal crops, radishes, fruit juices, beer, wine, spirits etc. It has a fruity characteristic odor that is commonly recognized in glues, nail polish remover, decaffeinating tea and coffee, and cigarettes. Due to its agreeable aroma and low cost, this chemical is commonly used and manufactured in large scale in the world, as over 1 million tons annually.
[Solubility in water]

8.3 g/100 mL (20 °C)
[Purification and water removal methods]

Ethyl acetate generally has a content of 95% to 98% containing a small amount of water, ethanol and acetic acid. It can be further purified as following: add 100mL of acetic anhydride into 1000mL of ethyl acetate; add 10 drops of concentrated sulfuric acid, heat and reflux for 4h to remove impurities such as ethanol and water, and then further subject to distillation. Distillate is oscillated by 20~30g of anhydrous potassium carbonate and further subject to re-distillation. The product has a boiling point of 77 °C and purity being over 99%.
[Uses]

Industry Applications Role/Benefit
Flavor and essence Food flavor Used largely to prepare bananas, pears, peaches, pineapple and grape scent food flavors, etc
Alcoholic essence Used slightly as fragrance volatile
Perfume essence Used slightly as fragrance volatile
Chemical manufacture Production of acetamide, acetyl acetate, methyl heptanone, etc Organic chemical raw materials
Production of organic acid Extracting agent
Laboratory Dilution and extraction Supply excellent dissolving capacity
Chromatographic analysis Standard material
Column chromatography and extractions Main component of mobile phase
Reaction solvent Be prone to hydrolysis and transesterification
Chemical analysis Thermometer calibration for sugar separation  Standard material
Determination of bismuth, boron, gold, molybdenum, platinum and thallium Solvent
Entomology Insect collecting and study Used as effective asphyxiant to kill the collected insect quickly without destroying it
Textile industry Cleaning agent Supply excellent dissolving capacity
Printing Flexographic and rotogravure printing Dissolve the resin, control the viscosity and modify the drying rate
Electronics industry Viscosity reducer Reduce the viscosity of resins used in photoresist formulations
Paint manufacture Solvent Dissolve and dilute the paints
Health & personal care products The formulation of nail polish, nail polish removers and other manicuring products Supply excellent dissolving capacity
Pharmaceutical Medicine manufacturing Extraction agent; intermediate
Cosmetics Aroma enhancer In perfume to enhance aroma
Others Tanning extracts Used for desulfurization of tanning, cigarette materials, oil field drilling, metal flotation, descaling, etc
Production of adhesive Solvent
Extract many compounds (phosphorus, cobalt, tungsten, arsenic) from aqueous solution Extracting agent
[Production]

Industrial production of ethyl acetate is mainly classified into three processes.

The first one is a classical Fischer esterification process of ethanol with acetic acid in presence of acid catalyst. This process needs acid catalyst2 such as sulphuric acid, hydrochloride acid, ptoluene sulfonic acid etc. This mixture converts to the ester in about 65% yield at room temperature. 
CH3CH2OH + CH3COOH ↔ CH3COOC2H5 + H2O
The reaction can be accelerated by acid catalysis and the equilibrium can be shifted to the right by removal of water.

The second one is Tishchenko Reaction of acetaldehyde using aluminium triethoxide as a catalyst. In Germany and Japan, most ethyl acetate is produced via the Tishchenko process. 
2 CH3CHO → CH3COOC2H5
This method has been proposed by two different routes; (i) dehydrogenative process, which uses copper or palladium based catalyst and (ii) the oxidative one, which employs, PdO supported catalysts.

The third one, which has been recently commercialized, is addition of acetic acid to ethylene using clay and heteroploy acid7 as a catalyst. 
CH2= CH2 + CH3COOH → CH3COOC2H5 
The processes, however, have some disadvantages; both the conventional esterification and addition of acetic acid to ethylene need stock tanks and apparatus for several feed stocks. Moreover, they use acetic acid that causes apparatus corrosion. Although Teshchenko Reaction uses only one feed and it is a non-corrosive material, it is difficult to handle acetaldehyde because is not available outside of petrochemical industrial area.
In such circumstances, an improved process of ethyl acetate production is strongly desired.
[Category]

Flammable liquid
[Toxicity grading]

poisoning
[Acute oral toxicity]

rat LD50: 5620 mg/kg; Oral-Mouse LD50: 4100 mg/kg
[Irritation data]

eye-people 400 PPM
[Hazardous characteristics of explosive]

explosive when mixed with air
[Flammability and hazard characteristics]

it is flammable in case of fire, high temperature, and oxidant with burning causing irritated smoke
[Storage characteristics]

Treasury: ventilation, low-temperature and dry; store it separately from oxidants
[Extinguishing agent]

dry powder, dry sand, carbon dioxide, foam, and 1211 fire extinguishing agent
[Professional standards]

TWA 1400 mg/m³; STEL 2000 mg/m³
Spectrum DetailBack Directory
[Spectrum Detail]

Ethyl acetate(141-78-6)IR1
Ethyl acetate(141-78-6)1HNMR
Ethyl acetate(141-78-6)Raman
Ethyl acetate(141-78-6)MS
Ethyl acetate(141-78-6)13CNMR
Ethyl acetate(141-78-6)IR2
Well-known Reagent Company Product InformationBack Directory
[Acros Organics]

Ethyl acetate, suitable for residue and pesticides analysis, for residue analysis(141-78-6)
[Alfa Aesar]

Ethyl acetate, Spectrophotometric Grade, 99.5+%(141-78-6)
[Sigma Aldrich]

141-78-6(sigmaaldrich)
[TCI AMERICA]

Ethyl Acetate,>99.5%(GC)(141-78-6)
141-78-6 suppliers list
Company Name: Shanghai Bojing Chemical Co.,Ltd.
Tel: +86-21-37122233
Fax: +86-21-37127788
Website: www.bj-chem.com
Company Name: Hebei Guanlang Biotechnology Co., Ltd.
Tel: +86-0311-66562153 whatsapp +8615203118427
Fax: +86-0311-66562153
Website: www.chemicalbook.com/ShowSupplierProductsList30475/0_EN.htm
Company Name: Hebei Guanlang Biotechnology Co., Ltd.
Tel: +8619930501651
Fax:
Website: www.chemicalbook.com/ShowSupplierProductsList31448/0.htm
Company Name: Hefei TNJ Chemical Industry Co.,Ltd.
Tel: 86-0551-65418684 18949823763
Fax: 86-0551-65418684
Website: www.tnjchem.com
Company Name: Xiamen AmoyChem Co., Ltd
Tel: +86 (0)592-605 1114
Fax:
Website: www.amoychem.com
Company Name: Chemwill Asia Co.,Ltd.
Tel: 86-21-51086038
Fax: 86-21-51861608
Website: www.chemwill.com
Company Name: Hubei Jusheng Technology Co.,Ltd.
Tel: 86-188-71490254
Fax:
Website: www.chemicalbook.com/ShowSupplierProductsList31316/0.htm
Company Name: Jinan Finer Chemical Co., Ltd
Tel: +86-531-88989536
Fax: +86-531-88989539
Website: www.finerchem.com
Company Name: Hebei Jimi Trading Co., Ltd.
Tel: +86 017772612259 +86 319 5273535
Fax:
Website: www.chemicalbook.com/ShowSupplierProductsList31327/0.htm
Company Name: Haihang Industry Co.,Ltd
Tel: 86-531-88032799
Fax: +86 531 8582 1093
Website: www.haihangindustry.com
Company Name: hdzhl biotechnology co., ltd
Tel: 86-13032617415
Fax:
Website: www.chemicalbook.com/ShowSupplierProductsList614110/0.htm
Company Name: ATK CHEMICAL COMPANY LIMITED
Tel: +86 21 5161 9050/ 5187 7795
Fax: +86 21 5161 9052/ 5187 7796
Website: www.atkchemical.com
Company Name: Yancheng Green Chemicals Co.,Ltd
Tel: 86-515-87883661
Fax: 86-515-87883652
Website: www.greenchem-china.com
Company Name: Hebei Chisure Biotechnology Co., Ltd.
Tel: +8613091036086; +8613292890173
Fax: +8613292893290
Website: www.chemicalbook.com/ShowSupplierProductsList30840/0.htm
Company Name: Hebei Ruishun Trade Co.,LTD
Tel: 17052563120
Fax:
Website: www.xiekun-china.com
Company Name: Hebei Huanhao Biotechnology Co., Ltd.
Tel: 86-0311-83975816 whatsapp +8618034554576
Fax: 86-0311-83975816
Website: www.chemicalbook.com
Company Name: career henan chemical co
Tel: +86-371-86658258
Fax:
Website: www.coreychem.com
Company Name: Mainchem Co., Ltd.
Tel: +86-0592-6210733
Fax: +86-0592-6210733
Website: www.mainchem.com
Tags:141-78-6 Related Product Information
10497-05-9 595-33-5 120-47-8 101-97-3 141-97-9 7695-91-2 64-17-5 147245-92-9 108-05-4 108-24-7 127-09-3 383-63-1 127-08-2 141-78-6 105-36-2 123-86-4 79-20-9 105-56-6