| Identification | Back Directory | [Name]
4,4'-DIHYDROXY-2-METHOXYCHALCONE | [CAS]
34221-41-5 | [Synonyms]
ECHINATIN
Retrochalcone
ECHINATIN(RG)(CALL)
4'-Dihydroxy-2-Methoxychalcone
4',4-DIHYDROXY-2-METHOXYCHALCONE
4,4'-DIHYDROXY-2-METHOXYCHALCONE
(E)-4,4'-Dihydroxy-2-methoxychalcone
4,4'-Dihydroxy-2-methoxy-trans-chalcone
Retrochalcone, 98%, from Glycyrrhiza uralensis Fisch.
3-(4-Hydroxy-2-Methoxyphenyl)-1-(4-hydroxyphenyl)prop-2-en-1-one
(E)-3-(4-Hydroxy-2-methoxyphenyl)-1-(4-hydroxyphenyl)-2-propen-1-one
(E)-3-(4-hydroxy-2-methoxyphenyl)-1-(4-hydroxyphenyl)prop-2-en-1-one
2-Propen-1-one,3-(4-hydroxy-2-Methoxyphenyl)-1-(4-hydroxyphenyl)-, (2E)- | [Molecular Formula]
C16H14O4 | [MDL Number]
MFCD00075719 | [MOL File]
34221-41-5.mol | [Molecular Weight]
270.28 |
| Chemical Properties | Back Directory | [Melting point ]
210°C (dec.) | [Boiling point ]
509.8±50.0 °C(Predicted) | [density ]
1.282±0.06 g/cm3 (20 ºC 760 Torr) | [storage temp. ]
Sealed in dry,2-8°C | [solubility ]
DMSO : 250 mg/mL (924.97 mM; Need ultrasonic) | [form ]
powder | [pka]
7.82±0.15(Predicted) | [color ]
Orange | [InChI]
InChI=1S/C16H14O4/c1-20-16-10-14(18)8-4-12(16)5-9-15(19)11-2-6-13(17)7-3-11/h2-10,17-18H,1H3/b9-5+ | [InChIKey]
QJKMIJNRNRLQSS-WEVVVXLNSA-N | [SMILES]
C(C1=CC=C(O)C=C1)(=O)/C=C/C1=CC=C(O)C=C1OC |
| Hazard Information | Back Directory | [Chemical Properties]
White crystalline powder, soluble in organic solvents such as methanol, ethanol, and DMSO, derived from licorice root. | [Uses]
Echinatin is used as an anticancer agent inhibiting DNA topoisomerase IB and Tyrosyl-DNA phosphodiesterase 1 inhibitors. | [in vivo]
Echinatin (20 and 40 mg/kg, i.p.) inhibits LPS-induced septic shock in mice by inhibiting NLRP3 inflammasome activation[2].
Echinatin (20-80 mg/kg, i.p.) shows cardioprotective effect, and relieves I/R-Induced Myocardial Injury in rats[3].
Echinatin (20 and 50?mg/kg, p.o.) inhibits tumor growth and inhibits the AKT/mTOR pathway of KYSE270-derived tumor mice xenografts[4].
| Animal Model: | LPS-induced septic shock in mice[1] | | Dosage: | 20 and 40 mg/kg | | Administration: | i.p. | | Result: |
Inhibited LPS-induced IL-1β and TNF-α production.
Reduced the proportion and the number of neutrophils in peritoneal lavage cells from mice. |
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