| Identification | Back Directory | [Name]
MRK-016 | [CAS]
342652-67-9 | [Synonyms]
MRK016;MRK 016
3-[3-tert-butyl-2-[(2-methyl-1,2,4-triazol-3-yl)methoxy]pyrazolo[1,5-d][1,2,4]triazin-7-yl]-5-methyl-1,2-oxazole
Pyrazolo[1,5-d][1,2,4]triazine, 3-(1,1-dimethylethyl)-7-(5-methyl-3-isoxazolyl)-2-[(1-methyl-1H-1,2,4-triazol-5-yl)methoxy]-
7-(5-Methyl-1,2-oxazol-3-yl)-3-(2-methyl-2-propanyl)-2-[(1-methyl-1H-1,2,4-triazol-5-yl)methoxy]pyrazolo[1,5-d][1,2,4]triazine | [Molecular Formula]
C17H20N8O2 | [MDL Number]
MFCD18086893 | [MOL File]
342652-67-9.mol | [Molecular Weight]
368.39 |
| Chemical Properties | Back Directory | [Melting point ]
175-176 °C(Solv: ethyl ether (60-29-7); methanol (67-56-1)) | [density ]
1.43±0.1 g/cm3(Predicted) | [storage temp. ]
under inert gas (nitrogen or Argon) at 2-8°C | [solubility ]
DMF: 2 mg/ml; DMSO: Slightly soluble; Ethanol: Slightly soluble; PBS (pH 7.2): 0.2 mg/ml | [form ]
A solid | [pka]
2.28±0.10(Predicted) | [color ]
White to off-white | [InChI]
1S/C17H20N8O2/c1-10-6-11(23-27-10)15-21-19-7-12-14(17(2,3)4)16(22-25(12)15)26-8-13-18-9-20-24(13)5/h6-7,9H,8H2,1-5H3 | [InChIKey]
QYSYOGCIDRANAR-UHFFFAOYSA-N | [SMILES]
CC(C)(C1=C2C=NN=C(N2N=C1OCC3=NC=NN3C)C4=NOC(C)=C4)C |
| Hazard Information | Back Directory | [Uses]
MRK 016 is an inverse benzodiazepine antagonist which may assist in mitigating inflammation-induced decrements in cognitive function. | [Biological Activity]
MRK-016 is an orally active, benzodiazepine site-targeting, alpha5-selective GABAA inverse agonist (Emax = -55%/α5, -16%/α1, -9%/α3, +6%/α2 of a EC20 GABA response using respective recombinant human αβ3γ2) with in vivo cognition-enhancing properties (0.3-3 mg/kg p.o. in r at Morris water maze test). | [in vivo]
MRK-016 does not enhance pentylenetetrazole-induced convulsions at 10 mg/kg via ip, or cause seizures at 30 mg/kg, via po for 20 days in mice. MRK-016 shows no obvious anxiogenic-like effects in rats at doses that occupy >95% of benzodiazepine (BZ) binding sites. MRK-016 (0.3, 1, and 3 mg/kg, p.o.) dose-dependently improves performance of rats hippocampal-dependent memory task[1]. MRK-016 (0.3-30 mg/kg, p.o.) causes good receptor occupancy in rats. MRK-016 (0.3, 1, or 3 mg/kg p.o.) shows cognition-enhancing activity in the delayed matching-to-position version of the Morris water maze. MRK-016 (1, 3, or 10 mg/kg i.p.) does not produce kindling in mice[2]. MRK-016 (3 mg/kg, i.p.) protects against LPS-induced learning/memory decrements in mice[3]. | [storage]
Store at +4°C |
|
| Company Name: |
Musechem
|
| Tel: |
+1-800-259-7612 |
| Website: |
www.musechem.com |
|