| Identification | More | [Name]
BOC-ABU-OH | [CAS]
34306-42-8 | [Synonyms]
BOC-2-ABU-OH
BOC-ABU(2)-OH
BOC-ABU(ALPHA)-OH
BOC-ABU-OH
BOC-ABU-OH DCHA
BOC-ALPHA-ABU-OH
BOC-AMINOBUTYRIC ACID
BOC-L-2ABU-OH
BOC-L-2-AMINOBUTANOIC ACID
BOC-L-2-AMINOBUTANOIC ACID DICYCLOHEXYLAMMONIUM SALT
BOC-L-2-AMINOBUTYRIC ACID
BOC-L-ABU-OH
BOC-L-ALPHA-AMINOBUTYRIC ACID
BOC-L-ALPHA-AMINOBUTYRIC ACID DICYCLOHEXYLAMMONIUM SALT
BOC-L-NHCH(CH2CH3)-COOH
L-2-(BOC-AMINO)BUTYRIC ACID
N-ALPHA-T-BOC-L-ALPHA-AMINOBUTYRIC ACID
N-ALPHA-T-BOC-L-ALPHA-AMINO-N-BUTYRIC ACID
N-ALPHA-T-BUTOXYCARBONYL-L-2-AMINO-BUTANOIC ACID
N-ALPHA-T-BUTOXYCARBONYL-L-ALPHA-AMINOBUTYRIC ACID | [EINECS(EC#)]
696-164-1 | [Molecular Formula]
C9H17NO4 | [MDL Number]
MFCD00037267 | [Molecular Weight]
203.24 | [MOL File]
34306-42-8.mol |
| Questions And Answer | Back Directory | [Preparation]
BOC-ABU-OH is generally synthesized from DL-2-aminobutyric acid. The specific synthesis steps are as follows: 10.3 g of DL-2-aminobutyric acid is dissolved in a mixture of 95 mL of 1 M NaOH solution and 65 mL of methanol. 27.5 mL of di-tert-butyl dicarbonate (i.e., Boc anhydride, 1.2 eq.) is added in an ice bath, and the mixture is slowly heated to room temperature with stirring for 12 hours. After the reaction is complete, methanol is removed by rotary evaporation, the pH is adjusted to 1-2 with 1 M hydrochloric acid, and the mixture is extracted with ethyl acetate (50 mL x 3), washed with saturated brine (40 mL x 2), and dehydrated with anhydrous sodium sulfate. Finally, rotary evaporation yields 18.9 g of colorless solid (93.4%). |
| Chemical Properties | Back Directory | [Melting point ]
70-74 °C
| [Boiling point ]
334.5±25.0 °C(Predicted) | [density ]
1.101±0.06 g/cm3(Predicted) | [Fp ]
113 °C | [storage temp. ]
Store at 0-5°C | [form ]
Solid | [pka]
4.00±0.10(Predicted) | [color ]
White to Almost white | [Optical Rotation]
[α]20/D 18.5±2°, c = 1% in methanol | [Water Solubility ]
Slightly soluble in water. | [BRN ]
6801706 | [Major Application]
peptide synthesis | [InChI]
InChI=1S/C9H17NO4/c1-5-6(7(11)12)10-8(13)14-9(2,3)4/h6H,5H2,1-4H3,(H,10,13)(H,11,12)/t6-/m0/s1 | [InChIKey]
PNFVIPIQXAIUAY-LURJTMIESA-N | [SMILES]
C(O)(=O)[C@@H](NC(OC(C)(C)C)=O)CC | [CAS DataBase Reference]
34306-42-8(CAS DataBase Reference) |
| Hazard Information | Back Directory | [Chemical Properties]
Light yellow powder | [Uses]
It is employed as a intermediate for pharmaceutical. | [reaction suitability]
reaction type: Boc solid-phase peptide synthesis |
|
| Company Name: |
Jinan Wald Chemical Co., Ltd. Gold
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| Telephone: |
0531-88773586 13210588999 |
| Website: |
https://www.chemicalbook.com/ShowSupplierProductsList1770979/0_EN.htm |
| Company Name: |
J & K SCIENTIFIC LTD.
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| Telephone: |
18210857532 18210857532 |
| Website: |
https://www.jkchemical.com |
| Company Name: |
Alfa Aesar
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| Telephone: |
400-6106006 |
| Website: |
http://chemicals.thermofisher.cn |
| Company Name: |
Energy Chemical
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| Telephone: |
400-0056266 |
| Website: |
www.energy-chemical.com |
| Company Name: |
Jia Xing Isenchem Co.,Ltd
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| Telephone: |
0573-85285100 18627885956 |
| Website: |
https://www.chemicalbook.com/ShowSupplierProductsList14265/0_EN.htm |
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