| Identification | More | [Name]
Boc-L-Glutamic acid | [CAS]
2419-94-5 | [Synonyms]
BOC-GLU-OH
BOC-GLUTAMIC ACID-OH
BOC-L-GLU-OH
BOC-L-GLUTAMIC ACID
BOC-L-GLUTAMIC ACID-OH
N-ALPHA-T-BOC-L-GLUTAMIC ACID
N-ALPHA-T-BUTOXYCARBONYL-L-GLUTAMIC ACID
N-ALPHA-TERT-BUTYLOXYCARBONYL-L-GLUTAMIC ACID
N-T-BUTOXYCARBONYL-L-GLUTAMIC ACID
N-(TERT-BUTOXYCARBONYL)-L-GLUTAMIC ACID
n-boc-l-glutamic acid
BOC-GLU
N-ALPHA-T-BUTYLOXYCARBONYL-L-GLUTAMIC ACID
BOC-L-GLUTAMIC ACID extrapure
N-(tert-Butoxycarbonyl)-L-glutamic acid ,98%
BOC-L-GLUTAMIC ACID, 99+% | [EINECS(EC#)]
1533716-785-6 | [Molecular Formula]
C10H17NO6 | [MDL Number]
MFCD00037297 | [Molecular Weight]
247.25 | [MOL File]
2419-94-5.mol |
| Questions And Answer | Back Directory | [Synthesis]
The benzyl ester of the amino acid derivative dissolved in methanol was hydrogenated on 10% Pd-C under a hydrogen atmosphere at 1 atm (less than 10% by weight of the amino acid benzyl ester or ether). After the reaction was complete, the catalyst was filtered off, and the filtrate was evaporated under vacuum to give the desired product. BOC-L-glutamic acid can be prepared from commercially available N-tert-butoxycarbonyl-L-glutamic acid benzyl ester (1.0 g, 3.0 mmol). The crude product was purified by rapid chromatography using 30% AcOEt/CH2Cl2/1% AcOH to obtain the desired product. BOC-L-glutamic acid, a white powder (680 mg, 93% yield). |
| Chemical Properties | Back Directory | [Appearance]
white to off-white crystalline powder | [Melting point ]
~110 °C (dec.) | [alpha ]
-15 º (c=1, CH30H) | [Boiling point ]
390.28°C (rough estimate) | [density ]
1.2868 (rough estimate) | [refractive index ]
-15 ° (C=1, MeOH) | [storage temp. ]
2-8°C
| [solubility ]
Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc. | [Water Solubility ]
Soluble in water | [form ]
powder to crystal | [pka]
3.83±0.10(Predicted) | [color ]
White to Almost white | [Optical Rotation]
[α]20/D 14.5±2°, c = 1% in methanol | [Detection Methods]
HPLC | [BRN ]
2418563 | [Major Application]
peptide synthesis | [InChI]
InChI=1S/C10H17NO6/c1-10(2,3)17-9(16)11-6(8(14)15)4-5-7(12)13/h6H,4-5H2,1-3H3,(H,11,16)(H,12,13)(H,14,15)/t6-/m0/s1 | [InChIKey]
AQTUACKQXJNHFQ-LURJTMIESA-N | [SMILES]
C(O)(=O)[C@H](CCC(O)=O)NC(OC(C)(C)C)=O | [CAS DataBase Reference]
2419-94-5(CAS DataBase Reference) |
| Safety Data | Back Directory | [Hazard Codes ]
Xn | [Risk Statements ]
R20/21/22:Harmful by inhalation, in contact with skin and if swallowed .
R36/37/38:Irritating to eyes, respiratory system and skin . | [Safety Statements ]
S22:Do not breathe dust .
S24/25:Avoid contact with skin and eyes .
S36:Wear suitable protective clothing .
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice . | [WGK Germany ]
3
| [HS Code ]
29241990 | [Storage Class]
11 - Combustible Solids |
| Hazard Information | Back Directory | [Chemical Properties]
white to off-white crystalline powder | [Uses]
N-Boc-L-glutamic acid is an N-Boc-protected form of L-Glutamic acid (G596960). L-Glutamic acid is a nonessential amino acid that is important to the mammalian central nervous system. L-Glutamic acid is also a neurotransmitter for cone photoreceptors in the human brain and is used as a treatment for patients who have liver disease accompanied by encephalopathy (a condition termed ‘hepatic coma’). | [reaction suitability]
reaction type: Boc solid-phase peptide synthesis |
|
| Company Name: |
J & K SCIENTIFIC LTD.
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18210857532 18210857532 |
| Website: |
https://www.jkchemical.com |
| Company Name: |
Alfa Aesar
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400-6106006 |
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http://chemicals.thermofisher.cn |
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Energy Chemical
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400-0056266 |
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www.energy-chemical.com |
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Jia Xing Isenchem Co.,Ltd
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0573-85285100 18627885956 |
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https://www.chemicalbook.com/ShowSupplierProductsList14265/0_EN.htm |
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