| Identification | Back Directory | [Name]
Fedovapagon | [CAS]
347887-36-9 | [Synonyms]
Fedovapagon
1,2-Pyrrolidinedicarboxamide, N2,N2-dimethyl-N1-[[2-methyl-4-[(2,3,4,5-tetrahydro-1H-1-benzazepin-1-yl)carbonyl]phenyl]methyl]-, (2S)- | [Molecular Formula]
C27H34N4O3 | [MDL Number]
MFCD19443737 | [MOL File]
347887-36-9.mol | [Molecular Weight]
462.58 |
| Chemical Properties | Back Directory | [Boiling point ]
740.0±60.0 °C(Predicted) | [density ]
1.203±0.06 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
DMSO: ≥ 125 mg/mL (270.22 mM) | [form ]
Solid | [pka]
13.38±0.40(Predicted) | [color ]
Off-white to light yellow |
| Hazard Information | Back Directory | [Uses]
Fedovapagon is a potent, nonpeptidic vasopressin V2 receptor agonists. | [in vivo]
Fedovapagon (1 mg/kg, oral administration) inhibits urine output with 81% inhibition rate in rats[1].
| Animal Model: | Brattleboro rats[1] | | Dosage: | 1 mg/kg, 3 mg/kg | | Administration: | Oral administration | | Result: | Reduced urine volume with almost full inhibition of urine output for 2 h.
Returned the urine to normal levels 5 h after dosing.
|
| [IC 50]
V2 Receptor; V2 Receptor: 24 nM (EC50) |
|
| Company Name: |
BOC Sciences
|
| Tel: |
|
| Website: |
https://www.bocsci.com |
| Company Name: |
Energy Chemical
|
| Tel: |
021-58432009 400-005-6266 |
| Website: |
http://www.energy-chemical.com |
|