| Identification | More | [Name]
1-(2-Pyridyl)piperazine | [CAS]
34803-66-2 | [Synonyms]
1-(2-PYRIDINYL)PIPERAZINE
1-(2-PYRIDYL)PIPERAZINE
1-PYRIDIN-2-YL-PIPERAZINE
2-(1-PIPERAZINYL)PYRIDINE
AKOS BBS-00003613
BUTTPARK 82\08-03
LABOTEST-BB LTBB000605
RARECHEM AH CK 0193
TIMTEC-BB SBB006445
Piperazine, 1-(2-pyridinyl)-
2-pyridyl piperazine
1-(2-PYRIDYL)PIPERAZINE, 99.5+%
2-(1-piperazino)pyridine
2-piperazinopyridine
1-(Pyridin-2-yl)piperazine 98%
N-(4-PYRIDYL) PIPERAZINE
1-PYRIDIN-2-YL-PIPERAZINE >98%
1-(2-Pyridyl)piperazine ,98% | [EINECS(EC#)]
252-220-3 | [Molecular Formula]
C9H13N3 | [MDL Number]
MFCD00006216 | [Molecular Weight]
163.22 | [MOL File]
34803-66-2.mol |
| Chemical Properties | Back Directory | [Appearance]
clear colourless to yellow liquid | [Melting point ]
92-94 | [Boiling point ]
120-122 °C/2 mmHg (lit.) | [density ]
1.072 g/mL at 25 °C(lit.)
| [refractive index ]
n20/D 1.595(lit.)
| [Fp ]
>230 °F
| [storage temp. ]
Flammables area | [solubility ]
Soluble in Chloroform, Methanol. | [form ]
Liquid | [pka]
8.63±0.10(Predicted) | [color ]
Clear colorless to yellow | [Water Solubility ]
>500 g/L (20 ºC) | [Sensitive ]
Air Sensitive | [Detection Methods]
GC,NMR | [BRN ]
140423 | [InChI]
1S/C9H13N3/c1-2-4-11-9(3-1)12-7-5-10-6-8-12/h1-4,10H,5-8H2 | [InChIKey]
GZRKXKUVVPSREJ-UHFFFAOYSA-N | [SMILES]
C1CN(CCN1)c2ccccn2 | [CAS DataBase Reference]
34803-66-2(CAS DataBase Reference) | [NIST Chemistry Reference]
1-(2-Pyridyl)piperazine(34803-66-2) |
| Safety Data | Back Directory | [Hazard Codes ]
Xi | [Risk Statements ]
R36/37/38:Irritating to eyes, respiratory system and skin . | [Safety Statements ]
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S36:Wear suitable protective clothing . | [RIDADR ]
2735 | [WGK Germany ]
3
| [F ]
10-34 | [Hazard Note ]
Irritant | [HazardClass ]
8 | [PackingGroup ]
II | [HS Code ]
29339900 | [Storage Class]
10 - Combustible liquids | [Hazard Classifications]
Eye Irrit. 2
Skin Irrit. 2
STOT SE 3 |
| Hazard Information | Back Directory | [Chemical Properties]
clear colourless to yellow liquid | [Uses]
1-(2-Pyridyl)piperazine is a compound that belongs to a class of selective α2-adrenoceptor antagonists. 1-(2-Pyridyl)piperazine shows sympatholytic activity. 1-(2-Pyridyl)piperazine is also a metaboli
te of Azaperone (A802200). | [General Description]
1-(2-Pyridyl)piperazine is a piperazine derivative. | [Synthesis]
Step 1: 0.1 g (0.63 mmol) of 2-bromopyridine and 0.065 g (0.75 mmol) of piperazine were placed in a dry 5 mL microwave reactor protected by nitrogen and reacted at 150 °C for 20 min. After completion of the reaction, it was cooled to room temperature. Step 2: The reaction mixture was filtered using diatomaceous earth and the filter cake was washed with ethyl acetate. Step 3: The solvent was removed by distillation under reduced pressure to obtain the crude product. Step 4: Purification of the crude product by silica gel column chromatography with eluent ratio of dichloromethane:methanol=4:1 to obtain 1-(pyridin-2-yl)piperazine in 54% yield. | [References]
[1] Patent: WO2008/153325, 2008, A1. Location in patent: Page/Page column 43
[2] Patent: WO2006/47415, 2006, A2. Location in patent: Page/Page column 37-38
[3] Journal of the American Chemical Society, 1949, vol. 71, p. 2731,2732
[4] Journal of Organic Chemistry, 1953, vol. 18, p. 1484,1487
[5] Patent: WO2008/62276, 2008, A2. Location in patent: Page/Page column 50 |
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