| Identification | Back Directory | [Name]
Necrostatin-7 (Nec-7) | [CAS]
351062-08-3 | [Synonyms]
Nec-7
Necrostatin-7
Necrostatin-7 (Nec-7)
Necrostatin-7 >=98% (HPLC), powder
5-[[3-(4-Fluorophenyl)-1H-pyrazol-4-yl]methylene]-2-imino-3-(2-thiazolyl)-4-thiazolidinone
4-Thiazolidinone, 5-[[3-(4-fluorophenyl)-1H-pyrazol-4-yl]methylene]-2-imino-3-(2-thiazolyl)-
(5Z)-5-[[5-(4-fluorophenyl)-1H-pyrazol-4-yl]methylidene]-2-imino-3-(1,3-thiazol-2-yl)-1,3-thiazolidin-4-one | [Molecular Formula]
C16H10FN5OS2 | [MDL Number]
MFCD02334728 | [MOL File]
351062-08-3.mol | [Molecular Weight]
371.41 |
| Chemical Properties | Back Directory | [Boiling point ]
613.4±65.0 °C(Predicted) | [density ]
1.63±0.1 g/cm3(Predicted) | [storage temp. ]
2-8°C | [solubility ]
DMSO: >10mg/mL (with warming) | [form ]
powder | [pka]
11.56±0.50(Predicted) | [color ]
yellow to tan | [InChI]
1S/C16H10FN5OS2/c17-11-3-1-9(2-4-11)13-10(8-20-21-13)7-12-14(23)22(15(18)25-12)16-19-5-6-24-16/h1-8,18H,(H,20,21) | [InChIKey]
SMJGLNVGTJLIRV-UHFFFAOYSA-N | [SMILES]
Fc1ccc(cc1)-c2n[nH]cc2C=C3SC(=N)N(C3=O)c4nccs4 |
| Hazard Information | Back Directory | [Uses]
Necrotatin-7 (Nec-7) is a potent necroptosis inhibitor with an EC50 of 10.6 μM. Necrotatin-7 does not inhibit recombinant RIP1 kinase[1]. | [Biological Activity]
Necrostatin-7 (Nec-7) is a potent inhibitor of necroptosisa regulated caspase-independent necrotic cell death pathwaydistinct from apoptosis. Nec-7 has a different profile from the other necrostatins as it does not inhibit RIP1 kinasesuggesting the possibility th at it may target an additional as yet unknown regulatory molecule in the pathway. | [storage]
+4°C | [References]
[1] Weihong Zheng, et al. Structure-activity relationship study of a novel necroptosis inhibitor, necrostatin-7. Bioorg Med Chem Lett. 2008 Sep 15;18(18):4932-5. DOI:10.1016/j.bmcl.2008.08.058 |
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| Company Name: |
Energy Chemical
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| Tel: |
021-58432009 400-005-6266 |
| Website: |
http://www.energy-chemical.com |
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