| Identification | More | [Name]
4,6-Dimethyl-2-methylsulfonylpyrimidine | [CAS]
35144-22-0 | [Synonyms]
2-METHANESULFONYL-4,6-DIMETHYL-PYRIMIDINE
4,6-DIMETHY-2-METHYLSULFONYLPYRIMIDINE
4,6-DIMETHYL-2-METHYLSULFONYLPYRIMIDINE
DLMSP
VITAS-BB TBB000242
4,6-dimethyl-2-mesyl-pyrimidine
4,6-Dimethyl-2-methylsilfonylpyrimidine
4,6-Dimethyl-2-(methylsulfonyl
4,6-DIMETHYL-2-METHYLSULFONYLPYRIMIDINE 99%
2-(Methylsulfonyl)-4,6-dimethylpyrimidine
Pyrimidine,4,6-dimethyl-2-(methylsulfonyl)- | [EINECS(EC#)]
609-077-0 | [Molecular Formula]
C7H10N2O2S | [MDL Number]
MFCD03788286 | [Molecular Weight]
186.23 | [MOL File]
35144-22-0.mol |
| Chemical Properties | Back Directory | [Melting point ]
84-86°C | [Boiling point ]
358.3±45.0 °C(Predicted) | [density ]
1.239 | [storage temp. ]
Sealed in dry,Room Temperature | [solubility ]
Chloroform (Slightly), Methanol (Slightly) | [form ]
Crystalline Solid | [pka]
-1.84±0.30(Predicted) | [color ]
Red-brown | [Detection Methods]
HPLC,NMR | [InChIKey]
ZHPSNGCLCHWTRG-UHFFFAOYSA-N | [CAS DataBase Reference]
35144-22-0(CAS DataBase Reference) |
| Hazard Information | Back Directory | [Chemical Properties]
White solid | [Uses]
4,6-Dimethyl-2-(methylsulfonyl)pyrimidine is a reactant used in the preparation of [(dimethylpyrimidinyl)oxy]diphenyl butyric acid derivatives as endothelin receptor antagonists. | [Synthesis]
General procedure for the synthesis of 2-methylsulfonyl-4,6-dimethylpyrimidines from 4,6-dimethyl-2-methylthiopyrimidines: 15.9 g (103 mmol) of 4,6-dimethyl-2-methylthiopyrimidines was dissolved in a solvent mixture of 120 mL of dichloromethane and 110 mL of water. Chlorine gas was passed through at 0 °C until the solution took on a yellow color and saturated. Upon completion of the reaction, the solution was purged with nitrogen to remove excess chlorine gas. The organic phase was separated and the aqueous phase was extracted with dichloromethane. The organic phases were combined and dried over anhydrous magnesium sulfate. The organic phase was concentrated under reduced pressure and the product was crystallized by the addition of ether to give 14 g (73% yield) of 2-methylsulfonyl-4,6-dimethylpyrimidine. The melting point of the product was 79-80 °C. 1H-NMR (270 MHz, CDCl3): δ 7.2 (1H, s), 3.4 (3H, s), 2.6 (6H, s). | [References]
[1] Patent: US6670367, 2003, B1. Location in patent: Page column 15-16
[2] Chemical and Pharmaceutical Bulletin, 1991, vol. 39, # 9, p. 2288 - 2300
[3] Journal of Medicinal Chemistry, 2004, vol. 47, # 11, p. 2776 - 2795 |
|
|