| Identification | More | [Name]
N-[4-[2-(2-Amino-4,7-dihydro-4-oxo-1H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoyl]-L-glutamic acid disodium salt hydrate | [CAS]
357166-30-4 | [Synonyms]
N-[4-[2-(2-Amino-4,7-dihydro-4-oxo-1H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoyl]-L-glutamic acid disodium salt hydrate
Pemetrexed disodium hydrate | [EINECS(EC#)]
814-356-7 | [Molecular Formula]
2(C20H19N5Na2O6).5(H2O) | [MDL Number]
MFCD13194950 | [Molecular Weight]
1032.84 | [MOL File]
357166-30-4.mol |
| Chemical Properties | Back Directory | [Melting point ]
274-276°C (dec.) | [storage temp. ]
Room Temperature | [solubility ]
DMSO, Methanol, Water | [form ]
Solid | [color ]
Off-White | [InChIKey]
AEZRDYKQLPDYEH-YTCXBBKHNA-N | [SMILES]
C(C1=CNC2NC(N)=NC(=O)C1=2)CC1C=CC(C(=O)N[C@H](C(=O)O)CCC(=O)O)=CC=1.[NaH].O |&1:20,r| | [CAS DataBase Reference]
357166-30-4(CAS DataBase Reference) |
| Hazard Information | Back Directory | [Uses]
Pemetrexed Disodium Hydrate is an chemotherapy drug for the treatment of pleural mesothelioma and non-small cell lung cancer. Pemetrexed Disodium Hydrate exhibit inhibitory activities towards thymidyl
ate synthase as well as other folate dependent enzymes. | [in vivo]
The group of mice treated with PC61 plus Pemetrexed demonstrates statistically longer survival than other groups. In a survival analysis, significantly better survival is observed in the group of mice treated with PC61 plus Pemetrexed compare with those treated with PC61 alone, rat IgG plus Pemetrexed, or no treatment[2]. | [storage]
Store at -20°C |
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| Company Name: |
J & K SCIENTIFIC LTD.
|
| Telephone: |
18210857532 18210857532 |
| Website: |
https://www.jkchemical.com |
| Company Name: |
Energy Chemical
|
| Telephone: |
400-0056266 |
| Website: |
www.energy-chemical.com |
| Company Name: |
Jia Xing Isenchem Co.,Ltd
|
| Telephone: |
0573-85285100 18627885956 |
| Website: |
https://www.chemicalbook.com/ShowSupplierProductsList14265/0_EN.htm |
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