| Identification | Back Directory | [Name]
5'-ISOBUTYLTHIO-5'-DEOXYADENOSINE | [CAS]
35899-54-8 | [Synonyms]
SIBA
5'-Isobutylthioadenosine
5'-S-Isobutylthioadenosine
5'-S-Isobutyl-5'-deoxyadenosine
5'-Deoxy-5'-isobutylthioadenosine
5'-ISOBUTYLTHIO-5'-DEOXYADENOSINE
5''-Deoxy-5''-S-isobutyladenosine
5’-deoxy-5’-s-isobutylthioadenosine
5'-S-(2-Methylpropyl)-5'-thioadenosine
Adenosine, 5'-S-(2-methylpropyl)-5'-thio-
5'-ISOBUTYLTHIOADENOSINE;5'-DEOXY-5'-ISOBUTYLTHIOADENOSINE
5μ-Deoxy-5μ-S-isobutylthioadenosine, 5μ-S-(2-Methylpropyl)-5μ-thioadenosine | [Molecular Formula]
C14H21N5O3S | [MDL Number]
MFCD00056008 | [MOL File]
35899-54-8.mol | [Molecular Weight]
339.41 |
| Chemical Properties | Back Directory | [Boiling point ]
631.2±65.0 °C(Predicted) | [density ]
1.63±0.1 g/cm3(Predicted) | [storage temp. ]
Keep in dark place,Inert atmosphere,2-8°C | [solubility ]
DMSO : ≥ 100 mg/mL (294.63 mM) | [form ]
Solid | [pka]
13.13±0.70(Predicted) | [color ]
Off-white to gray |
| Hazard Information | Back Directory | [Uses]
SIBA (5'-Isobutylthioadenosine) is a transmethylation inhibitor (SAH (HY-19528) analogue), with potent anti-proliferative activity. SIBA reversibly inhibits the production of HSV-1 by blocking methylation, specifically by blocking the 5' end-capping of viral mRNA. SIBA also inhibits the growth of tumour cells in vitro and metastatic spread in vivo. SIBA can be used in cancer, HSV-1 infection and anti-malaria studies[1][2][3]. | [in vivo]
SIBA (150 mg/kg; i.p.; twice weekly for 3 weeks) inhibits tumor growth in vivo[1].
SIBA (15 mg/kg; i.p.; thrice weekly for 4 weeks) inhibits metastatic spread of RMS-J1 cells in vivo[1]. | Animal Model: | C57BL/6 female mice (4-8 weeks old)[1]. | | Dosage: | 150 mg/kg | | Administration: | Intraperitoneal injection; twice weekly for 3 weeks. | | Result: | Significantly reduced the median number of lung metastases. |
| Animal Model: | Adult syngeneic Wistar AG rats (8-week-old; subcutaneously grafted with RMS-J1 cells)[1]. | | Dosage: | 15 mg/kg | | Administration: | Intraperitoneal injection; thrice weekly for 4 weeks. | | Result: | Inhibited in vivo metastatic spread of RMS-J1 cells, and showed median numbers of lung metastatic nodules was 26. |
| [IC 50]
Plasmodium; HSV-1 | [References]
[1] F Breillout , et al. Association of SIBA treatment and a Met-depleted diet inhibits in vitro growth and in vivo metastatic spread of experimental tumor cell lines. Clin Exp Metastasis. Jan-Feb 1988;6(1):3-16. DOI:10.1007/BF01580402
[2] B Jacquemont, et al. Inhibition of viral RNA methylation in herpes simplex virus type 1-infected cells by 5' S-isobutyl-adenosine. J Virol. 1977 Apr;22(1):160-7. DOI:10.1128/JVI.22.1.160-167.1977
[3] Lawrence F, et al. Effect of 5'-deoxy-5'-isobutylthioadenosine on putrescine uptake and polyamine biosynthesis by chick embryo fibroblasts. Biochem J. 1982 Jun 15;204(3):853-9. DOI:10.1042/bj2040853 |
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| Company Name: |
NewCan Biotech Limited
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| Telephone: |
+86-571-86912261 19975279805 |
| Website: |
https://www.newcanbio.com/ |
| Company Name: |
ChemeGen
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| Telephone: |
18818260767 |
| Website: |
https://www.chemegen.com |
| Company Name: |
Bide Pharmatech Ltd.
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| Telephone: |
400-1647117 13681763483 |
| Website: |
https://www.bidepharm.com/ |
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