| Identification | More | [Name]
TERT-BUTOXYCARBONYLAMINO-PHENYL-ACETIC ACID | [CAS]
3601-66-9 | [Synonyms]
BOC-DL-(PHENYL)GLY-OH
BOC-DL-PHG-OH
N-ALPHA-T-BUTOXYCARBONYL-DL-PHENYLGLYCINE
N-TERT-BUTOXYCARBONYL-DL-PHENYLGLYCINE
RARECHEM AK ML 0503
TERT-BUTOXYCARBONYLAMINO-PHENYL-ACETIC ACID
N-BOC-DL-PHENYLGLYCINE | [EINECS(EC#)]
1533716-785-6 | [Molecular Formula]
C13H17NO4 | [MDL Number]
MFCD00971063 | [Molecular Weight]
251.28 | [MOL File]
3601-66-9.mol |
| Hazard Information | Back Directory | [Uses]
Boc-DL-Phg-OH is a Glycine (HY-Y0966) derivative[1]. | [Synthesis]
General procedure for the synthesis of BOC-L-phenylglycine from di-tert-butyl dicarbonate and 2-amino-2-phenylacetic acid: DL-2-phenylglycine (5.0 g, 33 mmol) was dissolved in 1 N NaOH solution (132 mL). Subsequently, di-tert-butyl dicarbonate (19.0 mL, 82.7 mmol) was added and the reaction mixture was stirred at room temperature until the reaction was complete. N-tert-butoxycarbonyl-DL-phenylglycine was isolated as a white solid (7.61 g, 92% yield) by appropriate post-processing steps. | [References]
[1] Luckose F, et al. Effects of amino acid derivatives on physical, mental, and physiological activities. Crit Rev Food Sci Nutr. 2015;55(13):1793-1144. DOI:10.1080/10408398.2012.708368 |
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