| Identification | More | [Name]
4-(2-Chloroethyl)morpholine hydrochloride | [CAS]
3647-69-6 | [Synonyms]
2-CHLOROETHYLMORPHOLINE HYDROCHLORIDE
2-MORPHOLINOETHYL CHLORIDE HYDROCHLORIDE
4-(2-CHLOROETHYL)MORPHOLINE HYDROCHLORIDE
MOCPRF
MORPHOLINOETHYL CHLORIDE HYDROCHLORIDE
N-(2-CHLORETHYL)-MORPHOLINIUM CHLORIDE
N-(2-CHLOROETHYL)MORPHOLINE HYDROCHLORIDE
4-(2-chloroethyl)-morpholinhydrochloride
4-(2-chloroethyl)morpholinium chloride
N-(2-Chloroethyl)morpholine HCl
2-ChloroethylmorpholineHcl98%
2-Chloroethylmorpholine Hcl 98%
N-(2-Chloroethyl)morpholineHCl,[2-(N-Morpholino)ethylchlorideHCL]
MOC
2-(n-morpholino)ethyl chloride hydrochloride
N-(2-Chloroethyl)morpholine hydrochloride 99%
N-morpholinoethylchloride hydrochloride
1-Chloro-2-morpholinoethanehydrochloride
2-(4-Morpholinyl)ethyl chloride hydrochloride
Morpholine, 4-(2-chloroethyl)-, hydrochloride | [EINECS(EC#)]
222-881-2 | [Molecular Formula]
C6H13Cl2NO | [MDL Number]
MFCD00012797 | [Molecular Weight]
186.08 | [MOL File]
3647-69-6.mol |
| Chemical Properties | Back Directory | [Appearance]
White to beige crystalline powder | [Melting point ]
180-185 °C (dec.)(lit.)
| [storage temp. ]
Store below +30°C. | [solubility ]
Chloroform (Slightly, Heated), Methanol (Slightly), Water (Slightly) | [form ]
Hygroscopic Crystalline Powder | [color ]
White to beige | [PH]
4.5-5 (10g/l, H2O, 20℃) | [Water Solubility ]
soluble | [Sensitive ]
Hygroscopic | [Usage]
4-(2-Chloroethyl)morpholine hydrochloride (MOC) is used as intermediate for the synthesis of pharmaceuticals (e.g. floredil, morinamide, nimorazole and pholcodine). Product Data Sheet | [BRN ]
3684083 | [InChI]
InChI=1S/C6H12ClNO.ClH/c7-1-2-8-3-5-9-6-4-8;/h1-6H2;1H | [InChIKey]
NBJHDLKSWUDGJG-UHFFFAOYSA-N | [SMILES]
C1OCCN(CCCl)C1.[H]Cl | [CAS DataBase Reference]
3647-69-6(CAS DataBase Reference) | [EPA Substance Registry System]
3647-69-6(EPA Substance) |
| Safety Data | Back Directory | [Symbol(GHS) ]
 
GHS05,GHS06,GHS05,GHS06 | [Signal word ]
Danger | [Hazard statements ]
H301-H312-H314-H317-H412-H301-H312-H314-H317-H412 | [Precautionary statements ]
P260-P273-P280-P260-P273-P280-P303+P361+P353-P304+P340+P310-P305+P351+P338-P303+P361+P353-P304+P340+P310-P305+P351+P338 | [Hazard Codes ]
T | [Risk Statements ]
R21:Harmful in contact with skin.
R25:Toxic if swallowed.
R34:Causes burns.
R43:May cause sensitization by skin contact.
R52/53:Harmful to aquatic organisms, may cause long-term adverse effects in the aquatic environment . | [Safety Statements ]
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection .
S45:In case of accident or if you feel unwell, seek medical advice immediately (show label where possible) .
S61:Avoid release to the environment. Refer to special instructions safety data sheet . | [RIDADR ]
UN 2923 8/PG 3
| [WGK Germany ]
2
| [RTECS ]
QE0260000
| [Autoignition Temperature]
365 °C | [TSCA ]
Yes | [REACH Registrations]
Active | [HazardClass ]
8 | [PackingGroup ]
III | [HS Code ]
29349990 | [Storage Class]
6.1C - Combustible acute toxic Cat.3
toxic compounds or compounds which causing chronic effects | [Hazard Classifications]
Acute Tox. 3 Oral
Acute Tox. 4 Dermal
Aquatic Chronic 3
Eye Dam. 1
Skin Corr. 1B
Skin Sens. 1 | [Safety Profile]
Experimental
reproductive effects. Mutation data
reported. When heated to decomposition it
emits very toxic fumes of Cland NOx. | [Toxicity]
LD50 orally in Rabbit: 96 mg/kg LD50 dermal Rat 1502 mg/kg |
| Hazard Information | Back Directory | [Chemical Properties]
White to beige crystalline powder | [Uses]
4-(2-Chloroethyl)morpholine hydrochloride (MOC) is used as intermediate for the synthesis of pharmaceuticals (e.g. floredil, morinamide, nimorazole and pholcodine). Product Data Sheet | [Uses]
4-(2-Chloroethyl)morpholine is used in the preparation of potential DNA cross-linking antitumor agents as well as synthetic opiate analogues. 4-(2-Chloroethyl)morpholine may possess sickle-cell hemogl
obin aggregation inhibiting-activity. | [Synthesis]
General procedure for the synthesis of N-(2-chloroethyl)morpholine hydrochloride from morpholine and 2-chloroethanol: 5.0 mL of morpholine (57.5 mmol) and 4.6 mL of 2-chloroethanol (69.0 mmol) were added to 40 mL of toluene, and heated and refluxed for 2 hours. Upon completion of the reaction, the reaction solution was cooled to room temperature and then 8.4 mL (114 mmol) of thionyl chloride was added slowly dropwise under ice bath conditions. After the dropwise addition, the reaction was continued in the ice bath for 20 min, after which the ice bath was removed and the reaction mixture was allowed to stir for 6 h at room temperature. At the end of the reaction, toluene and unreacted thionyl chloride were removed by distillation under reduced pressure. The resulting residue was recrystallized from ethanol to give 7.9 g of N-(2-chloroethyl)morpholine hydrochloride. | [References]
[1] Patent: US2013/85140, 2013, A1. Location in patent: Paragraph 0074; 0075
[2] Patent: CN104710394, 2017, B. Location in patent: Paragraph 0039-0041 |
|
| Company Name: |
J & K SCIENTIFIC LTD.
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| Telephone: |
18210857532 18210857532 |
| Website: |
https://www.jkchemical.com |
| Company Name: |
Alfa Aesar
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| Telephone: |
400-6106006 |
| Website: |
http://chemicals.thermofisher.cn |
| Company Name: |
Energy Chemical
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| Telephone: |
400-0056266 |
| Website: |
www.energy-chemical.com |
| Company Name: |
Jia Xing Isenchem Co.,Ltd
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| Telephone: |
0573-85285100 18627885956 |
| Website: |
https://www.chemicalbook.com/ShowSupplierProductsList14265/0_EN.htm |
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