| Identification | Back Directory | [Name]
ANTIPAIN, DIHYDROCHLORIDE | [CAS]
37682-72-7 | [Synonyms]
ANTIPAIN
Antipain HCl
Antipain 2HCI
ANTIPAIN (2HCL)
ANTIPAIN HYDROCHLORIDE
Phe-Arg-Val-Arg-CHO.2HCl
ANTIPAIN, DIHYDROCHLORIDE
EZNA KIT ISOLATION FFPE RNA
ANTIPAIN ;PHE-ARG-VAL-ARG-CHO.2HCL
n-(nα-carbonyl-arg-val-arg-al)-phe
TRIS-GLYCINE BUFFER 10X PWD PROTEOMICS
N-(-N-ALPHA-CARBONYL-ARG-VAL-ARG-AL)PHE
N-[-N-ALPHA-CARBONYL-ARG-VAL-ARG-AL]-PHE HCL
ANTIPAIN HYDROCHLORIDE FROMMICROBIAL SOU RCE
antipain dihydrochloride from microbial source
N-(N-Carbonyl-Arg-Val-Arg-al)-Phe dihydrochloride
Antipain, Hydrochloride - CAS 37682-72-7 - Calbiochem
N-[-N-ALPHA-CARBONYL-ARG-VAL-ARG-AL]-PHE HYDROCHLORIDE
Antipain, Dihydrochloride - CAS 37682-72-7 - Calbiochem
[(S)-1-CARBOXY-2-PHENETHYL]-CARBAMOYL-ARG-VAL-ARG-ALDEHYDE
[(S)-1-CARBOXY-2-PHENYLETHYL]-CARBAMOYL-ARG-VAL-L-ARGININAL
[(S)-I-CARBOXY-2-PHENYLETHYL]-CARBAMOYL-L-ARG-L-VAL-ARGINAL
[(S)-1-CARBOXY-2-PHENYLETHYL]-CARBAMOYL-ARG-VAL-ARGINAL 2HCL
(S)-[1-CARBOXY-2-PHENYL-ETHYL]-CARBAMOYL-ARG-VAL-ARG-ALDEHYDE
Antipain dihydrochloride from microbial source protease inhibitor
[(S)-1-CARBOXY-2-PHENYLETHYL]CARBAMOYL-L-ARGINYL-L-VALYL-ARGININAL
[(S)-1-CARBOXY-2-PHENYLETHYL]-CARBAMOYL-ARG-VAL-ARG-AL HYDROCHLORIDE
l-valinamide,n(sup2)-(((1-carboxy-2-phenylethyl)amino)carbonyl)-l-arginyl-n-(
[(S)-1-CARBOXY-2-PHENYLETHYL]CARBAMOYL-L-ARGINYL-L-VALYLARGININAL HYDROCHLORIDE
L-Valinamide, N2-(1-carboxy-2-phenylethyl)aminocarbonyl-L-arginyl-N-4-(aminoiminomethyl)amino-1-formylbutyl-, dihydrochloride
N2-[[[(1S)-1-Carboxy-2-phenylethyl]amino]carbonyl]-L-arginyl-N-[4-[(aminoiminomethyl)amino]-1-formylbutyl]-L-valinamide hydrochloride (1:2)
L-Valinamide, N(sup 2)-(((1-carboxy-2-phenylethyl)amino)carbonyl)-L-arginyl-N-(4-((aminoiminomethyl)amino)-1-formylbutyl)-, dihydrochloride
L-Valinamide,N2-[[[(1S)-1-carboxy-2-phenylethyl]amino]carbonyl]-L-arginyl-N-[4-[(aminoiminomethyl)amino]-1-formylbutyl]-,hydrochloride (1:2)
(9S,12S)-1-aMino-16-benzyl-6-forMyl-12-(3-guanidinopropyl)-1-iMino-9-isopropyl-8,11,14-trioxo-2,7,10,13,15-pentaazaheptadecan-17-oic acid dihydrochloride | [EINECS(EC#)]
609-466-5 | [Molecular Formula]
C27H46Cl2N10O6 | [MDL Number]
MFCD00135957 | [MOL File]
37682-72-7.mol | [Molecular Weight]
677.62 |
| Chemical Properties | Back Directory | [Melting point ]
209-217 °C | [Boiling point ]
652.92°C (rough estimate) | [density ]
1.2423 (rough estimate) | [refractive index ]
1.6500 (estimate) | [storage temp. ]
-20°C | [solubility ]
H2O: 50 mg/mL
| [form ]
White powder | [color ]
White | [biological source]
Streptomyces sp. | [Water Solubility ]
0.01M in water | [Stability:]
Stable for 1 year from date of purchase as supplied. Solutions in distilled water may be stored at -20°C for up to 1 month. |
| Hazard Information | Back Directory | [Description]
Antipain is a protease inhibitor originally isolated from actinomycetes. It inhibits thrombokinase, plasmin, trypsin, and papain in vitro (IC50s = 20, 93, 0.26, and 0.16 μg/ml, respectively). Antipain (6-600 μg/ml) inhibits the morphological transformation of and increases frequency of chromosomal aberrations in Syrian hamster embryo cells induced by N-methyl-N''-nitro-N-nitroso-guanidine (MNNG). In vivo, antipain (25-100 mg/kg) suppresses urethan-induced formation of cleft palates and cleft lips in mice. | [Uses]
Concentrations for 50% inhibition (μg/ml): papain, 0.16trypsin, 0.26cathepsin A, 1.19cathepsin B, 0.59cathepsin D, 125plasmin, >93chymotrypsin and pepsin, >250It also has been reported to inhibit calpain I, (porcine) with Ki = 1.4 μM | [General Description]
Antipain is a protease inhibitor isolated from actinomycetes. It inhibits thrombokinase and blood coagulation. | [Biochem/physiol Actions]
Reversible inhibitor of serine/cysteine proteases and some trypsin-like serine proteases. Its action resembles leupeptin; however, its plasmin inhibition is less and its cathepsin A inhibition is more than that observed with leupeptin. Chronic administration of antipain can reduce the frequency of chemically induced transformation in BALB/c-/3T3 cells. | [in vivo]
The intact, cycling female mice received subcutaneous injections of Antipain dihydrochloride (3 mg) for 16 days, their uteri shows significant diminution in weight and total DNA when compared to untreated controls[4].
Antipain dihydrochloride (100 μg/g body wt; i.p.; at 12h intervals from 0 to 120 h or 240 to 360 h) shows inhibitory effect on Urethane-induced lung neoplasia in mice[5]. | [storage]
Store at -20°C | [References]
1) Umezawa?et al.?(1976),?Structures and activities of protease inhibitors of microbial origin; Method Enzymol.,?45?678
2) Gotoh?et al.?(2001),?Proteolytic activity and recombinant protein production in virus-infected Sf-9 insect cell cultures supplemented with carboxyl and cysteine protease inhibitors; J. Biosci. Bioeng.,?92?248
3) Hockensmith?et al. (2016), Identification and characterization of a chymotrypsin-like serine protease from periodontal pathogen, Tannerella forsythia; Microb. Pathog.,?100?37
4) Mat Amin?et al. (2004),?Proteinases in Naegleria Fowleri (strain NF3), a pathogenic amoeba: a preliminary study.; Trop. Biomed.,?21?57
5) Moriyyasu & Inoue (2008),?Use of protease inhibitor for detecting autophagy in plants; Methods Enzymol.,?451?557 |
|
| Company Name: |
|
| Tel: |
821-50328103-801 18930552037 |
| Website: |
https://www.chemicalbook.com/ShowSupplierProductsList13285/0.htm |
| Company Name: |
BOC Sciences
|
| Tel: |
1-631-485-4226; 16314854226 |
| Website: |
https://www.bocsci.com |
|