| Chemical Properties | Back Directory | [Melting point ]
274-276℃ (Decomposition) (ethanol ) | [Boiling point ]
610.3±55.0 °C(Predicted) | [density ]
1.37±0.1 g/cm3(Predicted) | [form ]
Solid | [pka]
12.66±0.60(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Chemical Properties]
White needle-shaped crystals, soluble in organic solvents such as methanol, ethanol, DMSO, etc., derived from Xihuangcao. | [Uses]
Enmein is isolated from I. serra with immunosuppressive effect[1]. | [Definition]
ChEBI: A natural product found in Isodon eriocalyx. | [in vivo]
Enmein (inject to ear; 6.52-13.04 mg/kg; 5 days) inhibits the xylene-induced ear swelling and inhibits IL-2 expression[1]. | Animal Model: | Balb/c mice[1] | | Dosage: | 6.52 mg/kg, 9.78 mg/kg or 13.04 mg/kg | | Administration: | Injected to ear; 6.52 mg/kg, 9.78 mg/kg or 13.04 mg/kg; 5 days | | Result: | Had inhibitory effect on IL-2 release in blood. |
| [References]
[1] Zhang Y, et al. Distinct immunosuppressive effect by Isodon serra extracts. Int Immunopharmacol. 2005 Dec;5(13-14):1957-65. Epub 2005 Jul 13. DOI:10.1016/j.intimp.2005.06.016
[2] Jiang B, et al. Cytotoxic ent-kaurane diterpenoids from Isodon sculponeata. Planta Med. 2002 Oct;68(10):921-5. DOI:10.1055/s-2002-34921 |
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