ChemicalBook--->CAS DataBase List--->3776-39-4

3776-39-4

3776-39-4 Structure

3776-39-4 Structure
IdentificationBack Directory
[Name]

enmein
[CAS]

3776-39-4
[Synonyms]

enmein
Isodonin
[Molecular Formula]

C20H26O6
[MDL Number]

MFCD01714945
[MOL File]

3776-39-4.mol
[Molecular Weight]

362.42
Chemical PropertiesBack Directory
[Melting point ]

274-276℃ (Decomposition) (ethanol )
[Boiling point ]

610.3±55.0 °C(Predicted)
[density ]

1.37±0.1 g/cm3(Predicted)
[form ]

Solid
[pka]

12.66±0.60(Predicted)
[color ]

White to off-white
Hazard InformationBack Directory
[Uses]

Enmein is isolated from I. serra with immunosuppressive effect[1].
[Definition]

ChEBI: A natural product found in Isodon eriocalyx.
[in vivo]

Enmein (inject to ear; 6.52-13.04 mg/kg; 5 days) inhibits the xylene-induced ear swelling and inhibits IL-2 expression[1].

Animal Model:Balb/c mice[1]
Dosage:6.52 mg/kg, 9.78 mg/kg or 13.04 mg/kg
Administration:Injected to ear; 6.52 mg/kg, 9.78 mg/kg or 13.04 mg/kg; 5 days
Result:Had inhibitory effect on IL-2 release in blood.
[References]

[1] Zhang Y, et al. Distinct immunosuppressive effect by Isodon serra extracts. Int Immunopharmacol. 2005 Dec;5(13-14):1957-65. Epub 2005 Jul 13. DOI:10.1016/j.intimp.2005.06.016
[2] Jiang B, et al. Cytotoxic ent-kaurane diterpenoids from Isodon sculponeata. Planta Med. 2002 Oct;68(10):921-5. DOI:10.1055/s-2002-34921
Spectrum DetailBack Directory
[Spectrum Detail]

enmein(3776-39-4)IR1
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