| Identification | More | [Name]
Ethyl 2-oxocyclopentanecarboxylate | [CAS]
611-10-9 | [Synonyms]
2-CARBETHOXYCYCLOPENTANONE
2-ETHOXYCARBONYLCYCLOPENTANONE
2-(ETHOXYCARBONYL)CYCLOPETNANONE
AKOS AU36-M83
CYCLOPENTANONE-2-CARBOXYLIC ACID ETHYL ESTER
ETHYL 2-CYCLOPENTANONE-1-CARBOXYLATE
ETHYL-2-CYCLOPENTANONECARBOXYLATE
ETHYL 2-OXOCYCLOPENTANECARBOXYLATE
ETHYL CYCLOPENTANONE-2-CARBOXYLATE
(R,S)-2-Oxo-cyclopentanecarboxylicacidethylester
2-Carbethoxy-1-cyclopentanone
2-Carboethoxycyclopentanone
2-Cyclopentanonecarboxylic acid ethyl ester
alpha-(Carboethoxy)cyclopentanone
Cylopenhtanone-2-carboxylicacidethylester
Ethyl 2-oxo-1-cyclopentanecarboxylate
Ethyl 2-oxoocyclopentanecarboxylate
Ethyl ester of 2-oxocyclopentanecarboxylic acid
Cyclopentanone-2-carboxylic acid ethyl ester~Ethyl 2-oxocyclopentanecarboxylate
Ehtyl 2-Oxocyclopentanecarboxylate | [EINECS(EC#)]
210-253-0 | [Molecular Formula]
C8H12O3 | [MDL Number]
MFCD00001412 | [Molecular Weight]
156.18 | [MOL File]
611-10-9.mol |
| Chemical Properties | Back Directory | [Appearance]
clear colourless to pale yellow liquid | [Boiling point ]
102-104 °C/11 mmHg (lit.) | [density ]
1.054 g/mL at 25 °C(lit.)
| [refractive index ]
n20/D 1.452(lit.)
| [Fp ]
172 °F
| [storage temp. ]
2-8°C
| [form ]
Liquid | [pka]
12.02±0.20(Predicted) | [color ]
Clear colorless to pale yellow | [Water Solubility ]
insoluble | [Detection Methods]
HPLC,NMR | [BRN ]
387787 | [InChI]
InChI=1S/C8H12O3/c1-2-11-8(10)6-4-3-5-7(6)9/h6H,2-5H2,1H3 | [InChIKey]
JHZPNBKZPAWCJD-UHFFFAOYSA-N | [SMILES]
C1(C(OCC)=O)CCCC1=O | [LogP]
0.330 (est) | [Uses]
Pharmaceutical intermediate. | [CAS DataBase Reference]
611-10-9(CAS DataBase Reference) | [NIST Chemistry Reference]
Cyclopentanecarboxylic acid, 2-oxo-, ethyl ester(611-10-9) |
| Safety Data | Back Directory | [Hazard Codes ]
Xi | [Risk Statements ]
R36/37/38:Irritating to eyes, respiratory system and skin . | [Safety Statements ]
S23:Do not breathe gas/fumes/vapor/spray (appropriate wording to be specified by the manufacturer) .
S24/25:Avoid contact with skin and eyes .
S36/37:Wear suitable protective clothing and gloves .
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice . | [WGK Germany ]
3
| [F ]
10 | [HazardClass ]
IRRITANT | [HS Code ]
29183000 |
| Raw materials And Preparation Products | Back Directory | [Raw materials]
Tetrahydrofuran-->Acetic acid-->Sodium-->Toluene-->Potassium tert-butoxide-->Diethyl adipate-->Cyclopentanecarboxylic acid, 1-bromo-2-oxo-, ethyl ester-->1,4-Dioxaspiro[4.4]nonane-6-carboxylic acid, ethyl ester | [Preparation Products]
3-Indolepropionic acid-->1-Cyclopentene-1-carboxylic acid, 2-(benzoylamino)-, ethyl ester-->Naphth[2,3-b]oxiren-2(1aH)-one, 7,7a-dihydro-7-hydroxy-1a,7-dimethyl--->2-CYCLOPENTANONE CARBOXYLATE-->3-oxo-2-pentylcyclopentaneacetic acid-->7-Hydroxy-2,3-dihydro-1H-cyclopenta[c]chromen-4-one-->MDL-29951-->Monoethyl Adipate |
| Hazard Information | Back Directory | [Hazard]
Vapors are toxic, as is skin contact. | [Description]
Ethyl 2-oxocyclopentanecarboxylate (EOCPC) is a multifunctional organic reagent that can be used as a pharmaceutical intermediate or raw material for chemical synthesis. EOCPC reacts with kaolinite to prepare intercalation compounds. It also participates in Michael reactions and diazonium transfer reactions for the preparation of other active ingredients. | [Chemical Properties]
clear colourless to pale yellow liquid | [Synthesis Reference(s)]
Journal of the American Chemical Society, 85, p. 207, 1963 DOI: 10.1021/ja00885a021
The Journal of Organic Chemistry, 55, p. 5037, 1990 DOI: 10.1021/jo00304a014
Tetrahedron Letters, 22, p. 1353, 1981 DOI: 10.1016/S0040-4039(01)90316-8 | [General Description]
Phase-transfer benzylation reaction of ethyl 2-oxocyclopentanecarboxylate with benzyl bromide in microreactor has been investigated. Ethyl 2-oxocyclopentanecarboxylate participates in cobalt (II) Schiff′s base complex catalyzed oxidation of primary and secondary alcohols. |
|
|