| Identification | Back Directory | [Name]
Eflone | [CAS]
3801-06-7 | [Synonyms]
eflone
Flarex
U 17323
NSC 47438
Nolpitantium
Oxylone Acetate
Eflone USP/EP/BP
Flumetholon acetate
FLUROMETHOLONE ACETATE
fluorometholone acetate
FLUOROMETHALONE ACETATE
FluoroMetholone 17- acetate
FLUOROMETHOLONE ACETATE (200 MG)
6α-Methyl-9α-fluoro-17-acetoxy-21-deoxyprednisolone
17-(Acetyloxy)-9-fluoro-11β-hydroxy-6α-methylpregna-1,4-diene-3,20-dione
9-fluoro-11b,17-dihydroxy-6a-methylpregna-1,4-diene-3,20-dione 17-acetate
9-fluoro-11β,17-dihydroxy-6α-methylpregna-1,4-diene-3,20-dione 17-acetate
(6α,11β)-17-(Acetyloxy)-9-fluoro-11-hydroxy-6-Methylpregna-1,4-diene-3,20-dione
9-fluoro-11beta,17-dihydroxy-6alpha-methylpregna-1,4-diene-3,20-dione 17-acetate
Pregna-1,4-diene-3,20-dione,17-(acetyloxy)-9-fluoro-11-hydroxy-6-Methyl-, (6a,11b)-
Pregna-1,4-diene-3,20-dione, 17-(acetyloxy)-9-fluoro-11-hydroxy-6-methyl-, (6α,11β)- | [EINECS(EC#)]
223-270-3 | [Molecular Formula]
C24H31FO5 | [MDL Number]
MFCD00866062 | [MOL File]
3801-06-7.mol | [Molecular Weight]
418.498 |
| Chemical Properties | Back Directory | [Melting point ]
230-232° | [alpha ]
D +28° (chloroform) | [Boiling point ]
532.1±50.0 °C(Predicted) | [density ]
1.24±0.1 g/cm3(Predicted) | [storage temp. ]
-20°C Freezer | [solubility ]
Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly) | [form ]
Solid | [pka]
13.01±0.70(Predicted) | [color ]
Off-White to Light Yellow | [Major Application]
pharmaceutical (small molecule) | [InChIKey]
YRFXGQHBPBMFHW-ZGNMMXMRNA-N | [SMILES]
[C@]12(F)[C@@]([H])(O)C[C@]3(C)[C@](CC[C@@]3([H])[C@]1([H])C[C@]([H])(C)C1=CC(=O)C=C[C@]21C)(C(=O)C)OC(=O)C |&1:0,2,6,8,11,13,16,25,r| |
| Safety Data | Back Directory | [WGK Germany ]
WGK 3 | [HS Code ]
2937220000 | [Storage Class]
6.1C - Combustible acute toxic Cat.3
toxic compounds or compounds which causing chronic effects | [Hazard Classifications]
Repr. 1B |
| Hazard Information | Back Directory | [Chemical Properties]
Off-White to Pale Yellow Solid | [Uses]
Fluorometholone Acetate is a glucocorticoid; anti-inflammatory. | [Definition]
ChEBI: A steroid ester resulting from the formal condensation of the 17-hydroxy function of fluorometholone with acetic acid. Used in the treatment of steroid responsive inflammatory conditions of the palpebral and bulbar conjunctiva, cornea, and anterior segment
of the eye. | [Brand name]
Flarex (Alcon). | [Synthesis]
The preparation method of the fluorometholone acetate (Eflone) comprises the
following steps: taking a compound shown as a formula II as a raw
material, and sequentially carrying out dechlorination reaction,
esterification reaction, methylation reaction, hydrogenation reaction,
fermentation dehydrogenation reaction, epoxy reaction and ring-opening
reaction to prepare the fluorometholone acetate.
 | [in vivo]
Hourly topical administration of 0.1% Fluorometholone acetate ophthalmic suspension produced, on the average, a 47% reduction in the polymorphonuclear leukocytes invading the cornea during an experimentally induced inflammatory keratitis in New Zealand albino rabbits (1.5-2.0 kg). Fluorometholone acetate (0.1%) formulated as a high-viscosity carbomer gel and applied at three-hour intervals reduced invading leukocytes in the cornea an average of 48%, an effect not significantly different from hourly administration of the suspension[1]. | [IC 50]
CA Ⅱ |
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