| Identification | More | [Name]
Potassium 3-methoxy-3-oxopropanoate | [CAS]
38330-80-2 | [Synonyms]
KMM
MALONIC ACID MONOMETHYL ESTER POTASSIUM
METHYL MONO POTASSIUM MALONATE
METHYL POTASSIUM MALONATE
MONO-METHYL MALONATE POTASSIUM SALT
MONOMETHYL MONOPOTASSIUM MALONATE
POTASSIUM 3-METHOXY-3-OXOPROPANOATE
POTASSIUM METHYL MALONATE
POTASSIUM MONOMETHYL MALONATE
Potassiummonomethylmallonate
Propanedioic acid, monomethyl ester, potassium salt
Malonic acid methyl ester potassium salt
Monomethyl malonate potassium salt, Potassium monomethyl malonate
Malonic acid 1-methyl 3-potassium salt
Malonic acid 1-potassium 3-methyl ester salt
Propanedioic acid 1-methyl 3-potassium salt | [EINECS(EC#)]
253-886-8 | [Molecular Formula]
C4H5KO4 | [MDL Number]
MFCD00014021 | [Molecular Weight]
156.18 | [MOL File]
38330-80-2.mol |
| Chemical Properties | Back Directory | [Appearance]
White crystalline powder | [Melting point ]
200 °C
| [storage temp. ]
Inert atmosphere,Room Temperature | [solubility ]
Soluble in methanol. | [form ]
Crystalline Powder | [color ]
White | [PH]
pH(50g/l, 25℃) : 5.5～8.0 | [BRN ]
3633585 | [InChI]
InChI=1S/C4H6O4.K/c1-8-4(7)2-3(5)6;/h2H2,1H3,(H,5,6);/q;+1/p-1 | [InChIKey]
WWTULTKUWBKVGV-UHFFFAOYSA-M | [SMILES]
C(=O)(OC)CC([O-])=O.[K+] | [CAS DataBase Reference]
38330-80-2(CAS DataBase Reference) |
| Safety Data | Back Directory | [Hazard Codes ]
Xi | [Risk Statements ]
R36/37/38:Irritating to eyes, respiratory system and skin . | [Safety Statements ]
S37/39:Wear suitable gloves and eye/face protection .
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice . | [WGK Germany ]
3
| [F ]
3 | [HS Code ]
29171910 | [Storage Class]
11 - Combustible Solids |
| Hazard Information | Back Directory | [Chemical Properties]
White crystalline powder | [Uses]
A protein advanced glycosylation inhibitor. | [Synthesis]
The general procedure for the synthesis of monomethyl malonate potassium salt from dimethyl malonate was as follows: referring to the literature method, dimethyl malonate (40.0 mmol), water (40.0 mmol), and ethanol (45 mL) were added to a 250 mL two-necked round-bottomed flask, and the mixture was stirred and mixed. The mixture was reacted in an oil bath at 40°C for 2 hours. Subsequently, a solution of potassium tert-butoxide (40.0 mmol) in ethanol (45 mL) was slowly added dropwise over 30 minutes. After the dropwise addition, the reaction was continued with stirring in a 40°C oil bath until the feedstock was completely consumed (the progress of the reaction was monitored by GC analysis). Upon completion of the reaction, the ethanol solvent was slowly evaporated using a rotary evaporator, followed by the addition of 20 mL of diethyl ether. The resulting solid product was collected by filtration and washed sequentially with a 1:1 mixture of ether and ethanol (5 mL × 2) and pure ether (10 mL × 3). The washed solid was transferred to a round-bottomed flask and dried under vacuum at 50 °C for 10 h. The final potassium salt of monomethyl malonate was obtained in 85% yield. | [References]
[1] Tetrahedron, 2012, vol. 68, # 9, p. 2113 - 2120
[2] Angewandte Chemie - International Edition, 2011, vol. 50, # 19, p. 4470 - 4474
[3] Patent: CN106467492, 2017, A. Location in patent: Paragraph 0129; 0130; 0131
[4] Journal of Physical Chemistry, 1987, vol. 91, # 19, p. 5129 - 5134
[5] Patent: US6172257, 2001, B2 |
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