| Identification | Back Directory | [Name]
2-Chloro-6-methylpyrazine | [CAS]
38557-71-0 | [Synonyms]
2-Methyl-6-chloropyrazine
6-Methyl-2-chloropyrazine
2-CHLORO-6-METHYLPYRAZINE
Pyrazine, 2-chloro-6-methyl-
2-Chloro-6-methylpyrazine97%
2-Chloro-6-methylpyrazine 97%
2-Chloro-6-methyl-1,4-diazine
2-Chloro-6-methylpyrazine >
2-Chloro-6-methylpyrazine, >=98%
2-Chloro-6-methylpyrazine ISO 9001：2015 REACH | [Molecular Formula]
C5H5ClN2 | [MDL Number]
MFCD00055032 | [MOL File]
38557-71-0.mol | [Molecular Weight]
128.56 |
| Chemical Properties | Back Directory | [Melting point ]
49-52 | [Boiling point ]
83°C/35mmHg(lit.) | [density ]
1.234±0.06 g/cm3(Predicted) | [storage temp. ]
Keep in dark place,Sealed in dry,Room Temperature | [form ]
powder to crystal | [pka]
-0.89±0.10(Predicted) | [color ]
White to Almost white | [InChI]
1S/C5H5ClN2/c1-4-2-7-3-5(6)8-4/h2-3H,1H3 | [InChIKey]
CKUVSPQGYLELRG-UHFFFAOYSA-N | [SMILES]
Cc1cncc(Cl)n1 |
| Hazard Information | Back Directory | [Chemical Properties]
Solid | [Uses]
2-Chloro-6-methylpyrazine was used in the synthesis of palm site inhibitors of HCV NS5B polymerase and potent dipeptidyl peptidase IV inhibitors. | [Synthesis]
Step 3: To a 5L sealed reaction tube was added (6-chloropyrazin-2-yl)acetic acid (220 g, 1.27 mol, 1.00 equiv) and deionized water (3L). The reaction mixture was stirred at 130 °C overnight. Upon completion of the reaction, the mixture was cooled to room temperature and subsequently extracted with ether (2 x 3 L). The organic phases were combined, dried over anhydrous sodium sulfate, filtered, and concentrated under reduced pressure to afford 238 g (73% yield) of 2-chloro-6-methylpyrazine as a yellow solid. | [References]
[1] Patent: US2015/31674, 2015, A1. Location in patent: Paragraph 0325; 0322 |
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