| Identification | More | [Name]
FLUNIXIN MEGLUMINE | [CAS]
38677-85-9 | [Synonyms]
2-[[2-METHYL-3-(TRIFLUOROMETHYL)PHENYL]AMINO]-3-PYRIDINECARBOXYLIC ACID MEGLUMINE SALT
BANAMINE
BUTANIXIN
FLUNIXINE MEGLUMINE SALT
FLUNIXIN MEGLUMINE
FLUNIXIN MEGLUMINE SALT
Flunixin VETRANAL
FlunixinMeglumineBase
3-Pyridinecarboxylic acid, 2-2-methyl-3-(trifluoromethyl)phenylamino-
2-(2-Methyl-3-trifluoromethylanilino)nicotinic Acid
2-[[2-Methyl-3-(trifluoromethyl)phenyl]amino]-3-pyridinecarboxylic Acid
Sch 14714
2-[2-Methyl-3-(trifluoromethyl)phenylamino]nicotinic acid | [Molecular Formula]
C21H28F3N3O7 | [MDL Number]
MFCD01725419 | [Molecular Weight]
491.46 | [MOL File]
38677-85-9.mol |
| Chemical Properties | Back Directory | [Appearance]
Crystalline Solid | [Melting point ]
136.6-137.4 °C | [Boiling point ]
378.7±42.0 °C(Predicted) | [density ]
1.403±0.06 g/cm3(Predicted) | [solubility ]
H2O: freely soluble
| [form ]
solid
| [pka]
5.82(at 25℃) | [color ]
off-white
| [Stability:]
Stable. Incompatible with strong bases, strong oxidizing agents. | [Usage]
Cyclooxigenase inhibitor. Anti-inflammatory; analgesic; antipyretic | [Major Application]
forensics and toxicology
pharmaceutical (small molecule) | [InChI]
1S/C14H11F3N2O2/c1-8-10(14(15,16)17)5-2-6-11(8)19-12-9(13(20)21)4-3-7-18-12/h2-7H,1H3,(H,18,19)(H,20,21) | [InChIKey]
NOOCSNJCXJYGPE-UHFFFAOYSA-N | [SMILES]
Cc1c(Nc2ncccc2C(O)=O)cccc1C(F)(F)F | [CAS DataBase Reference]
38677-85-9(CAS DataBase Reference) | [EPA Substance Registry System]
3-Pyridinecarboxylic acid, 2-[[2-methyl-3-(trifluoromethyl)phenyl]amino]- (38677-85-9) |
| Safety Data | Back Directory | [Symbol(GHS) ]
GHS06 | [Signal word ]
Danger | [Hazard statements ]
H301 | [Precautionary statements ]
P264-P270-P301+P310-P405-P501 | [Hazard Codes ]
Xi,Xn | [Risk Statements ]
R36/37/38:Irritating to eyes, respiratory system and skin .
R22:Harmful if swallowed. | [Safety Statements ]
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S36:Wear suitable protective clothing . | [RIDADR ]
UN2811 6.1/PG 3 | [WGK Germany ]
3
| [RTECS ]
LZ4367000
| [HS Code ]
2933399990 | [Storage Class]
6.1C - Combustible acute toxic Cat.3
toxic compounds or compounds which causing chronic effects | [Hazard Classifications]
Acute Tox. 3 Oral |
| Hazard Information | Back Directory | [Chemical Properties]
Crystalline Solid | [Uses]
Cyclooxigenase inhibitor. Anti-inflammatory; analgesic; antipyretic | [Definition]
ChEBI: A pyridinemonocarboxylic acid that is nicotinic acid substituted at position 2 by a 2-methyl-3-(trifluoromethyl)phenylamino group. A relatively potent non-narcotic, nonsteroidal analgesic with anti-inflammatory, anti-endotoxic and anti-pyretic properties;
sed in veterinary medicine (usually as the meglumine salt) for treatment of horses, cattle and pigs. | [General Description]
Flunixin is classified under the group of non-steroidal anti-inflammatory drugs (NSAIDs). | [in vivo]
Flunixin meglumine (intravenous injection; 1.1 mg/kg; once) treatment inhibits the formation of exudate PGE2 and serum TXB2[1]. | Animal Model: | Male sheep injected with Carrageenan[1] | | Dosage: | 1.1 mg/kg | | Administration: | Intravenous injection; 1.1 mg/kg; once | | Result: | Inhibited Carrageenan-induced exudate PGE2 formation (Emax, 100%, IC50, <0.4 nM) and serum TXB2 generation (Emax, 100%, IC50, 17 nM) for up to 32 h. |
| [IC 50]
COX-1: 0.55 μM (IC50); COX-2: 3.24 μM (IC50) |
|
| Company Name: |
Sigma-Aldrich
|
| Telephone: |
021-61415566 800-8193336 |
| Website: |
https://www.sigmaaldrich.cn |
| Company Name: |
parabiochem
|
| Telephone: |
025-83453382-8005 |
| Website: |
www.parabiochem.cn |
| Company Name: |
Rhawn Reagent
|
| Telephone: |
400-400-1332688 18019345275 |
| Website: |
http://www.rhawn.cn |
| Company Name: |
TOSUN PHARM
|
| Telephone: |
020-66392521-118 18922260391 |
| Website: |
www.toref.cn/ |
| Company Name: |
AFINE CHEMICALS LIMITED
|
| Telephone: |
+86-571-85134551 +86-18958018566 |
| Website: |
www.afinechem.com/index.html |
|