| Identification | More | [Name]
3-Bromo-2-methylpyridine | [CAS]
38749-79-0 | [Synonyms]
2-METHYL-3-BROMOPYRIDINE
3-BROMO-2-METHYLPYRIDINE
3-BROMO-2-PICOLINE
Pyridine, 3-bromo-2-methyl-
3-bromo-2-methylpridine
3-Bromo-5-fluoro-2-methoxypyrdine
2-METHYL-3-BROMOPYRIDINE 98+%
3-BROMO-2-METHYLPYRIDINE (3-BROMO-2-PICOLINE)
2-bromo-4-bromophenol | [EINECS(EC#)]
625-249-8 | [Molecular Formula]
C6H6BrN | [MDL Number]
MFCD00191224 | [Molecular Weight]
172.02 | [MOL File]
38749-79-0.mol |
| Chemical Properties | Back Directory | [Appearance]
colorless liquid | [Boiling point ]
76°C/17mm | [density ]
1.495 | [refractive index ]
1.5604 | [Fp ]
174°F | [storage temp. ]
Inert atmosphere,Room Temperature | [form ]
Liquid | [pka]
3.59±0.10(Predicted) | [color ]
Clear, colorless to brown | [InChI]
InChI=1S/C6H6BrN/c1-5-6(7)3-2-4-8-5/h2-4H,1H3 | [InChIKey]
AIPWPTPHMIYYOX-UHFFFAOYSA-N | [SMILES]
C1(C)=NC=CC=C1Br | [CAS DataBase Reference]
38749-79-0(CAS DataBase Reference) |
| Safety Data | Back Directory | [Hazard Codes ]
Xn,Xi | [Risk Statements ]
R22:Harmful if swallowed.
R37/38:Irritating to respiratory system and skin .
R41:Risk of serious damage to eyes.
R36/37/38:Irritating to eyes, respiratory system and skin .
R20/21/22:Harmful by inhalation, in contact with skin and if swallowed . | [Safety Statements ]
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S36/39:Wear suitable protective clothing and eye/face protection .
S36:Wear suitable protective clothing . | [WGK Germany ]
3 | [Hazard Note ]
Irritant | [HazardClass ]
IRRITANT | [HS Code ]
29333990 |
| Hazard Information | Back Directory | [Chemical Properties]
colorless liquid | [Uses]
Conversion to the corresponding pyridine carboxaldehyde via peroxide initiated NBS gem-dibromination followed by hydrolysis. | [Synthesis]
The general procedure for synthesizing 2-methyl-3-bromopyridine from 2-methylpyridine was as follows: 2-methylpyridine (46.6 g) was slowly added dropwise to aluminum chloride (200 g) with reference to the method of Example 182, and the mixture was stirred continuously at 100°C. Maintaining the same temperature, bromine (40.0 g) was slowly added dropwise to the mixture over a period of 1 hour, followed by continued stirring for 30 minutes. Upon completion of the reaction, the mixture was cooled and poured into ice water, followed by addition of concentrated hydrochloric acid until the mixture was acidified. The resulting solution was washed with ethyl acetate and the aqueous layer was alkalized with 8 mol/L aqueous sodium hydroxide. The alkalized aqueous layer was extracted with ether and the extract was washed with saturated brine and dried with anhydrous sodium sulfate. Subsequently, the extract was concentrated under reduced pressure. The residue was purified by silica gel column chromatography (eluent: hexane-ether=10:1) to afford 2-methyl-3-bromopyridine as a colorless oil (yield 5.09 g, 12% yield). The structure of the product was confirmed by 1H-NMR (CDCl3): δ 2.67 (3H, s), 6.98-7.03 (1H, m), 7.78-7.82 (1H, m), 8.40-8.44 (1H, m). | [References]
[1] Patent: US2007/60623, 2007, A1. Location in patent: Page/Page column 50 |
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