| Identification | Back Directory | [Name]
MURISTERONE A | [CAS]
38778-30-2 | [Synonyms]
MURA
Muristerone
MURISTERONE A
Ecdysonic sterol
MURISTERONE A(P)
MURISTERONE A USP/EP/BP
MURISTERONE A, IPOMOEA SPP
5B, 7-CHOLESTENE-2B,3B,5A,11A,14,20,22-HEPTOL-6-ONE
2B,3B,5A,11A,14,20,22-HEPTAHYDROXY-5B-7-CHOLESTEN-6-ONE
2β,3β,5β,11α,14α,20R,22R-Heptahydroxycholest-7-en-6-one
(22R)-2β,3β,5,11α,14,20,22-Heptahydroxy-5β-cholest-7-en-6-one
MurA, 2β,3β,5β,11α,14α,20R,22R-Heptahydroxycholest-7-en-6-one
5BETA,7-CHOLESTENE-2BETA,3BETA,5ALPHA,11ALPHA,14,20,22-HEPTOL-6-ONE
(2β,3β,5β,11α,22R)-2,3,5,11,14,20,22-Heptahydroxycholest-7-en-6-one
2BETA,3BETA,5ALPHA,11ALPHA,14,20,22-HEPTAHYDROXY-5BETA,7-CHOLESTEN-6-ONE
2BETA,3BETA,5BETA,11ALPHA,14ALPHA,20R,22R-HEPTAHYDROXYCHOLEST-7-EN-6-ONE
(2beta,3beta,5beta,11alpha,22R)-2,3,5,11,14,20,22-Heptahydroxy-cholest-7-en-6-one
Cholest-7-en-6-one, 2,3,5,11,14,20,22-heptahydroxy-, (2beta,3beta,5beta,11alpha,22R)- | [Molecular Formula]
C27H44O8 | [MDL Number]
MFCD00056450 | [MOL File]
38778-30-2.mol | [Molecular Weight]
496.63 |
| Chemical Properties | Back Directory | [Boiling point ]
707.2±60.0 °C(Predicted) | [density ]
1.33±0.1 g/cm3(Predicted) | [storage temp. ]
−20°C | [solubility ]
Soluble in DMSO | [form ]
solid | [pka]
11.78±0.70(Predicted) | [color ]
white |
| Hazard Information | Back Directory | [Description]
Muristerone A is a natural analog of 20-hydroxyecdysone . It is an agonist of the ecdysteroid receptor (Kd = 1 nM), a nuclear receptor that heterodimerizes with a retinoid X receptor ortholog and regulates arthropod development. Muristerone A is used as an agonist in ecdysone-inducible gene expression systems in mammalian cells. However, it inhibits apoptosis in the human colon carcinoma cell line RKO by inducing the upregulation of Bcl-xL, suggesting limitations in its use in certain types of studies. | [Uses]
Muristerone A, an ecdysteroid, is widely used for the induction of ecdysteroid-dependent transcription in mammalian cells. | [Biological Activity]
Ecdysone analog that acts as an inducer of ecdysone-inducible gene expression systems in mammalian cells and transgenic animals. Stimulates Bcl-XL mRNA transcription and inhibits TRAIL- and hFasL-induced apoptosis in RKO cells. | [storage]
Store at -20°C | [References]
[1] A C ZELHOF. Identification and characterization of a Drosophila nuclear receptor with the ability to inhibit the ecdysone response.[J]. Proceedings of the National Academy of Sciences of the United States of America, 1995, 92 23: 10477-10481. DOI: 10.1073/pnas.92.23.10477
[2] T M LANDON. Characterization and partial purification of the Drosophila Kc cell ecdysteroid receptor.[J]. The Journal of Biological Chemistry, 1988, 263 10: 4693-4697.
[3] MARKUS LEZZI. Ligand-induced heterodimerization between the ligand binding domains of the Drosophila ecdysteroid receptor and ultraspiracle[J]. The FEBS journal, 2009, 269 13: 3237-3245. DOI: 10.1046/j.1432-1033.2002.03001.x
[4] D NO R M E T P Yao. Ecdysone-inducible gene expression in mammalian cells and transgenic mice.[J]. Proceedings of the National Academy of Sciences of the United States of America, 1996, 93 8: 3346-3351. DOI: 10.1073/pnas.93.8.3346
[5] E SAEZ. Identification of ligands and coligands for the ecdysone-regulated gene switch.[J]. Proceedings of the National Academy of Sciences of the United States of America, 2000, 97 26: 14512-14517. DOI: 10.1073/pnas.260499497
[6] I OEHME M Z S B?sser. Agonists of an ecdysone-inducible mammalian expression system inhibit Fas Ligand- and TRAIL-induced apoptosis in the human colon carcinoma cell line RKO[J]. Cell Death and Differentiation, 2005, 13 2: 189-201. DOI: 10.1038/sj.cdd.4401730 |
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| Company Name: |
GK Chemicals
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+91-7207279444 |
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www.www.info@gkchemicalss.com |
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