| Identification | Back Directory | [Name]
CK-0993548 | [CAS]
388604-55-5 | [Synonyms]
CK-548
CK-0993548
2-(3-Bromophenyl)-3-(5-chloro-2-hydroxyphenyl)-4-thiazolidinone | [Molecular Formula]
C15H11BrClNO2S | [MDL Number]
MFCD01844273 | [MOL File]
388604-55-5.mol | [Molecular Weight]
384.68 |
| Chemical Properties | Back Directory | [Boiling point ]
614.4±55.0 °C(Predicted) | [density ]
1.667±0.06 g/cm3(Predicted) | [storage temp. ]
2-8°C | [solubility ]
DMSO: soluble24mg/mL | [form ]
solid | [pka]
8.99±0.48(Predicted) |
| Hazard Information | Back Directory | [Uses]
CK-548 (CK-0993548) is a Arp2/3 complex inhibitor with the IC50 of 11 μM. CK-548 inhibits HIV-1 nuclear migration and infection[1][2]. | [References]
[1] B. J. Nolen, et al. Characterization of two classes of small molecule inhibitors of Arp2/3 complex. Nature.
[2] Spear M, et al. HIV-1 triggers WAVE2 phosphorylation in primary CD4 T cells and macrophages, mediating Arp2/3-dependent nuclear migration. J Biol Chem. 2014;289(10):6949-6959. DOI:10.1074/jbc.M113.492132 |
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