| Identification | More | [Name]
N-Hydroxyethylphthalimide | [CAS]
3891-07-4 | [Synonyms]
2-(2-hydroxyethyl)-1h-isoindole-1,3(2h)-dione
2-PHTHALIMIDOETHANOL
AKOS BBS-00004429
N-(2-HYDROXYETHYL)PHTHALIMIDE
N-(BETA-HYDROXYETHYL)PHTHALIMIDE
N-HYDROXYETHYLPHTHALIMIDE
TIMTEC-BB SBB003638
1H-Isoindole-1,3(2H)-dione, 2-(2-hydroxyethyl)-
2-(2-hydroxyethyl)-1h-isoindole-3(2h)-dione
2-Hydroxyethylphthalimide
Phthalimide, N-(2-hydroxyethyl)-
N-hydroethyl phthalimide
N-(2-Hydroxyethyl)phthalimide, 98+% | [EINECS(EC#)]
223-434-4 | [Molecular Formula]
C10H9NO3 | [MDL Number]
MFCD00005903 | [Molecular Weight]
191.18 | [MOL File]
3891-07-4.mol |
| Chemical Properties | Back Directory | [Appearance]
white crystalline powder | [Melting point ]
126-128 °C(lit.)
| [Boiling point ]
326.92°C (rough estimate) | [density ]
1.2722 (rough estimate) | [refractive index ]
1.5310 (estimate) | [storage temp. ]
Inert atmosphere,Room Temperature | [solubility ]
DMSO (Slightly), Methanol (Slightly) | [form ]
Crystalline Powder | [pka]
14.40±0.10(Predicted) | [color ]
White | [BRN ]
147214 | [InChI]
InChI=1S/C10H9NO3/c12-6-5-11-9(13)7-3-1-2-4-8(7)10(11)14/h1-4,12H,5-6H2 | [InChIKey]
MWFLUYFYHANMCM-UHFFFAOYSA-N | [SMILES]
C1(=O)C2=C(C=CC=C2)C(=O)N1CCO | [CAS DataBase Reference]
3891-07-4(CAS DataBase Reference) | [NIST Chemistry Reference]
N-2-hydroxyethyl phthalimide(3891-07-4) | [EPA Substance Registry System]
3891-07-4(EPA Substance) |
| Safety Data | Back Directory | [Symbol(GHS) ]
GHS07 | [Signal word ]
Warning | [Hazard statements ]
H319 | [Precautionary statements ]
P264-P280-P305+P351+P338-P337+P313 | [Hazard Codes ]
Xi | [Risk Statements ]
R36/37/38:Irritating to eyes, respiratory system and skin . | [Safety Statements ]
S22:Do not breathe dust .
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection .
S24/25:Avoid contact with skin and eyes . | [WGK Germany ]
3
| [TSCA ]
Yes | [REACH Registrations]
Active | [HS Code ]
29251900 | [Storage Class]
11 - Combustible Solids | [Hazard Classifications]
Eye Irrit. 2 |
| Hazard Information | Back Directory | [Chemical Properties]
white crystalline powder | [Uses]
N-(2-Hydroxyethyl)phthalimide is used as a reagent to synthesize (-)-R-rolipram is a phosphodiesterase 4 inhibitor that is used to treat depression. N-(2-Hydroxyethyl)phthalimide is also used as a reagent to synthesize FR252921, a compound that acts as an immunosuppressant. Amlodipine Impurity 6 | [Synthesis Reference(s)]
Organic Syntheses, Coll. Vol. 4, p. 106, 1963
The Journal of Organic Chemistry, 24, p. 1122, 1959 DOI: 10.1021/jo01090a601 | [General Description]
N-(2-Hydroxyethyl)phthalimide is the precursor for chloromethyl ethers used in the synthesis of purine acyclic nucleosides. | [Synthesis]
A synthetic method of N-(2-Hydroxyethyl)phthalimide. It was prepared by allowing 147.2g (1.0 mole) of phthalimide to react in an autoclave with 53.0g (1.20 moles) of ethylene oxide in the presence of 1.47g (1%) of active chromium III tri-2-ethylhexanoate (COT) and 400 ml of methylisobutyl ketone (MiBK) at 160° to 165°C for two hours. On cooling, the N-(2-Hydroxyethyl)phthalimide crystallized and was collected by filtration. A 94.7% yield of the hydroxyethyl imide was obtained.
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