| Identification | More | [Name]
4-METHYL-2-(3-PYRIDINYL)-1,3-THIAZOLE-5-CARBOXYLIC ACID | [CAS]
39091-01-5 | [Synonyms]
2-(3-PYRIDYL)-4-METHYLTHIAZOLE-5-CARBOXYLIC ACID
4-METHYL-2-(3-PYRIDINYL)-1,3-THIAZOLE-5-CARBOXYLIC ACID
4-METHYL-2-(PYRIDIN-3-YL)-1,3-THIAZOLE-5-CARBOXYLIC ACID
4-METHYL-2-PYRIDIN-3-YL-THIAZOLE-5-CARBOXYLIC ACID
AKOS B029403
ASINEX-REAG BAS 07676575
ASISCHEM C71524
BUTTPARK 51\01-30
TIMTEC-BB SBB011441
2-(3-PYRIDYL)-4-METHYLTHIAZOLE-5-CARBOX&
4-METHYL-2-PYRID-3-YLTHIAZOLE-5-CARBOXYLIC ACID
4-Methyl-2-(pyridin-3-yl)-1,3-thiazole-5-carboxylic acid 95% | [Molecular Formula]
C10H8N2O2S | [MDL Number]
MFCD00171753 | [Molecular Weight]
220.25 | [MOL File]
39091-01-5.mol |
| Chemical Properties | Back Directory | [Melting point ]
244-248 °C (dec.)(lit.) | [Boiling point ]
459.0±55.0 °C(Predicted) | [density ]
1.381±0.06 g/cm3(Predicted) | [solubility ]
DMF: 1.5 mg/ml; DMSO: 2 mg/ml; DMSO:PBS(pH7.2) (1:1): 0.5 mg/ml | [form ]
A crystalline solid | [pka]
1.71±0.37(Predicted) | [InChI]
1S/C10H8N2O2S/c1-6-8(10(13)14)15-9(12-6)7-3-2-4-11-5-7/h2-5H,1H3,(H,13,14) | [InChIKey]
CJLQNROYBZEUGH-UHFFFAOYSA-N | [SMILES]
Cc1nc(sc1C(O)=O)-c2cccnc2 | [CAS DataBase Reference]
39091-01-5(CAS DataBase Reference) |
| Safety Data | Back Directory | [Hazard Codes ]
Xi | [Risk Statements ]
R36/37/38:Irritating to eyes, respiratory system and skin . | [Safety Statements ]
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S36:Wear suitable protective clothing . | [WGK Germany ]
3
| [Hazard Note ]
Irritant | [HazardClass ]
IRRITANT | [HS Code ]
2934100090 | [Storage Class]
13 - Non Combustible Solids | [Hazard Classifications]
Eye Irrit. 2
Skin Irrit. 2
STOT SE 3 |
| Hazard Information | Back Directory | [Description]
2-(3-pyridyl)-4-methyl-Thiazole-5-carboxylic acid is a synthetic intermediate useful for pharmaceutical synthesis. | [Uses]
2-(3-Pyridyl)-4-methyl-thiazole-5-carboxylic acid is a synthetic intermediate useful for pharmaceutical synthesis. | [Synthesis]
1. Synthesis of ethyl 2-bromo-4-methylthiazole-5-carboxylate: Ethyl 2-amino-4-methylthiazole-5-carboxylate is diazotized and brominated (with CuBr₂).
2. Synthesis of target product: The bromo compound from step 1 undergoes Suzuki coupling with pyridine |
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