| Identification | More | [Name]
2-Amino-5-fluorobenzotrifluoride | [CAS]
393-39-5 | [Synonyms]
2-AMINO-5-FLUOROBENZOTRIFLUORIDE
4-FLUORO-2-(TRIFLUOROMETHYL)ANILINE
4-fluoro-2-(trifluoromethyl)benzenamine
5-FLUORO-2-AMINOBENZOTRIFLUORIDE
ALPHA,ALPHA,ALPHA,4-TETRAFLUORO-O-TOLUIDINE
2-(Trifluoromethyl)-4-fluoroaniline
Benzenamine,4-fluoro-2-(trifluoromethyl)-
o-Toluidine, alpha,alpha,alpha,4-tetrafluoro-
2-Amino-5-fluorobenzotrifluoride, 97% (4-Fluoro-2-(trifluoromethyl)aniline)
5-Fluoro–2-Nitrotrifluoromethylbenzene
4-Fluoro-2-(Trifluoromethyl)an
2-Amino-5-fluorobenzotrifluoride 99%
2-Amino-5-fluorobenzotrifluoride99%
ALPHA,ALPHA,ALPHA,4-TETRAFLUORO-ORTHO-TOLUIDINE
ALPHA,ALPHA,ALPHA-4-TETRAFLUORO-2-TOLUIDINE
4-fluoro-1-nitro-2-(trifluoromethyl)benzene,4-fluoro-2-trifluoromethylaniline
2-Amino-5-fluorobenzotrifluoride, α,α,α,4-Tetrafluoro-o-toluidine
2-Amino-5-fluorobenzotrifluoride ,98% | [EINECS(EC#)]
206-886-7 | [Molecular Formula]
C7H5F4N | [MDL Number]
MFCD00007831 | [Molecular Weight]
179.11 | [MOL File]
393-39-5.mol |
| Safety Data | Back Directory | [Hazard Codes ]
Xn,Xi | [Risk Statements ]
R20/21/22:Harmful by inhalation, in contact with skin and if swallowed .
R36/37/38:Irritating to eyes, respiratory system and skin . | [Safety Statements ]
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S36:Wear suitable protective clothing . | [WGK Germany ]
3
| [Hazard Note ]
Irritant | [HazardClass ]
6.1 | [HazardClass ]
IRRITANT | [HS Code ]
29039990 | [Storage Class]
10 - Combustible liquids | [Hazard Classifications]
Acute Tox. 4 Oral
Eye Irrit. 2
Skin Irrit. 2
STOT SE 3 |
| Hazard Information | Back Directory | [Chemical Properties]
clear light yellow to pale brown liquid | [Uses]
4-Fluoro-2-(trifluoromethyl)aniline was used in the preparation of 2-[4-(3-bromophenyl)-7-chloro-6-methyl-2-oxo-2H-chromen-3-yl]-N-[4-fluoro-2-(trifluoro-methyl)phenyl]acetamide. | [Synthesis]
General procedure for the synthesis of 2-amino-5-fluorobenzotrifluoride from trifluoroiodomethane and 4-fluoroaniline: a 25 mL Schlenk tube was filled with a magnetic stirring bar, and 4-fluoroaniline (1.2 mmol, 3.0 eq.) or heterocyclic amine (0.8 mmol, 2.0 eq.), potassium carbonate (K2CO3, 0.8 mmol, 2.0 eq.) and fac- Ir(ppy)3 (2.6 mg, 0.004 mmol, 1 mol%). The reaction vessel was evacuated and displaced three times with argon (Ar), then trifluoroiodomethane (CF3I) stock solution (0.56 mL, 0.71 mmol/mL in 1,2-dichloroethane or 0.36 mL, 1.11 mmol/mL, 1.0 equiv in DMSO) and anhydrous 1,2-dichloroethane (3 mL) were added. The cap of the tube was screwed on tightly and the reaction was stirred for 24 h at room temperature under the illumination of a blue LED (12 W). Upon completion of the reaction, the reaction mixture was filtered through a diatomaceous earth pad and washed with ethyl acetate (3 x 5 mL). The filtrate was concentrated and the residue was purified by silica gel column chromatography to afford the target product 2-amino-5-fluorobenzotrifluoride. | [References]
[1] Tetrahedron Letters, 2017, vol. 58, # 41, p. 3939 - 3941 |
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