| Identification | More | [Name]
2-AMINO-N-METHYLBENZAMIDE | [CAS]
4141-08-6 | [Synonyms]
2-AMINO-N-METHYLBENZAMIDE
BUTTPARK 34\02-07
Benzamide, 2-amino-N-methyl-(9CI)
2-Amino-N-methylbenzamide 98%
Benzamide, 2-amino-N-methyl- | [Molecular Formula]
C8H10N2O | [MDL Number]
MFCD00060602 | [Molecular Weight]
150.18 | [MOL File]
4141-08-6.mol |
| Questions And Answer | Back Directory | [Synthesis]
2-Amino-N-methylbenzamide can be prepared from indocyanine anhydride. The reaction formula is shown in the figure below: Figure 1. Reaction formula for the preparation of 2-amino-N-methylbenzamide from indocyanine anhydride. |
| Chemical Properties | Back Directory | [Melting point ]
75 °C | [Boiling point ]
346.7±25.0 °C(Predicted) | [density ]
1.137±0.06 g/cm3(Predicted) | [storage temp. ]
Keep in dark place,Inert atmosphere,Room temperature | [solubility ]
DMSO, Methanol | [form ]
Solid | [pka]
14.73±0.46(Predicted) | [color ]
White | [CAS DataBase Reference]
4141-08-6(CAS DataBase Reference) |
| Safety Data | Back Directory | [Hazard Codes ]
Xi | [Risk Statements ]
R36/37/38:Irritating to eyes, respiratory system and skin . | [Safety Statements ]
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection . | [Hazard Note ]
Irritant | [HazardClass ]
IRRITANT | [HS Code ]
2924297099 |
| Hazard Information | Back Directory | [Chemical Properties]
White Solid | [Uses]
2-Amino-N-methylbenzamide is a plant safening agent selected from auxins, auxin precursors, metabolites or derivatives, and acetaminophen or a derivative. Safening examples are provided for fertilizer
s, fungicides, insecticides, and herbicides. | [Definition]
ChEBI: N-Methylanthranilamide is an aminobenzoic acid. | [General Description]
2-AMINO-N-METHYLBENZAMIDE is a key synthetic intermediate used to construct the core skeleton of FAK inhibitors (PA-DPPYs). It first reacts with 2,4,5-trichloropyrimidine (or 2,4-dichloro-5-nitropyrimidine) to form the 2-(2-chloro-5-substituted-pyrimidin-4-ylamino) -N-methylbenzamide intermediate, which is subsequently coupled with an aromatic amine containing a phosphate group to ultimately yield a series of bispyrimidine derivatives exhibiting anti-pancreatic cancer activity[6]. | [References]
[1] Bioorganic and Medicinal Chemistry Letters, 2011, vol. 21, # 1, p. 164 - 167
[2] Patent: WO2011/140338, 2011, A1. Location in patent: Page/Page column 41
[3] Patent: WO2012/92880, 2012, A1. Location in patent: Page/Page column 61
[4] Patent: WO2004/80980, 2004, A1. Location in patent: Page 110-111
[5] Patent: US2013/225585, 2013, A1. Location in patent: Paragraph 0215; 0216 |
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| Company Name: |
J & K SCIENTIFIC LTD.
|
| Telephone: |
18210857532 18210857532 |
| Website: |
https://www.jkchemical.com |
| Company Name: |
Energy Chemical
|
| Telephone: |
400-0056266 |
| Website: |
www.energy-chemical.com |
|