| Identification | More | [Name]
6-Methyl-4-phenylchroman-2-one | [CAS]
40546-94-9 | [Synonyms]
3,4-DIHYDRO-6-METHYL-4-PHENYL-2H-1-BENZOPYRAN-2-ONE
6-METHYL-4-PHENYLCHROMAN-2-ONE
6-Methyl-4-phenyl-3,4-dihydrovanillin
6-Methyl-4-Phenyl-3,4-Dihydrovanillin(ForTolterodine-L-Tartrate)
forTolterodine-L-tartrate
6-METHYL-4-PHENYL-3,4-DIHYDRO-2H-1-BENZOPYRAN-2-ONE
6-METHYL-4-PHENYL-CHROMAN-ONE
6-METHYL-4-PHENYL-3,4-DIHYDRO-2H-1-BENZOPYRAN | [Molecular Formula]
C16H14O2 | [MDL Number]
MFCD03695019 | [Molecular Weight]
238.28 | [MOL File]
40546-94-9.mol |
| Chemical Properties | Back Directory | [Melting point ]
68-70°C | [Boiling point ]
230°C/16mmHg(lit.) | [density ]
1.166±0.06 g/cm3(Predicted) | [storage temp. ]
Sealed in dry,Room Temperature | [solubility ]
DMSO (Slightly), Methanol (Slightly) | [form ]
Solid | [color ]
White to Off-White | [Major Application]
pharmaceutical | [InChI]
1S/C16H14O2/c1-11-7-8-15-14(9-11)13(10-16(17)18-15)12-5-3-2-4-6-12/h2-9,13H,10H2,1H3 | [InChIKey]
SUHIZPDCJOQZLN-UHFFFAOYSA-N | [SMILES]
CC1=CC=C(O2)C(C(C3=CC=CC=C3)CC2=O)=C1 | [CAS DataBase Reference]
40546-94-9(CAS DataBase Reference) |
| Hazard Information | Back Directory | [Chemical Properties]
White Solid | [Uses]
Intermediate in the production of Tolterodine. | [Synthesis]
The general procedure for the synthesis of 6-methyl-4-phenylbenzodihydropyran-2-one from p-cresol and trans-cinnamic acid is as follows: a mixture of 0.5 kg cinnamic acid, 0.401 kg p-cresol and 2.2 L xylene was stirred for 15 minutes. 0.132 kg of concentrated sulfuric acid was slowly added under continuous stirring. After addition of the acid, the reaction mixture was stirred at 140-145 °C for the reaction. After completion of the reaction, the reaction was cooled to room temperature and then washed with 1.0 L of deionized water. The reaction mixture was further cooled to 10-15 °C, and 0.5 N NaOH solution was added to deionized water, and the reaction mixture was added dropwise and stirred at the same temperature for 1 hour. The organic layer was separated and washed with deionized water. The organic layer was completely distilled under reduced pressure (30-40 mmHg) to give 3,4-dihydro-6-methyl-4-phenyl-2H-benzopyran-2-one (Yield: 0.78 kg, Yield: 97%).HPLC purity: > 95%. | [References]
[1] Patent: WO2010/46801, 2010, A2. Location in patent: Page/Page column 15
[2] Research on Chemical Intermediates, 2016, vol. 42, # 7, p. 6407 - 6422
[3] Organic Process Research and Development, 2005, vol. 9, # 3, p. 314 - 318
[4] Tetrahedron Letters, 2012, vol. 53, # 33, p. 4469 - 4472
[5] Tetrahedron, 2014, vol. 70, # 34, p. 5221 - 5233 |
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