405911-09-3

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405911-09-3 Structure

Identification	Back Directory
[Name] 3-[3-[N-(2-CHLORO-3-TRIFLUOROMETHYLBENZYL)-(2,2-DIPHENYLETHYL)AMINO]PROPYLOXY]PHENYLACETIC ACID HYDROCHLORIDE
[CAS] 405911-09-3
[Synonyms] GW3965 CS-1391 GW3965 (GW 3965 GW 3965 HYDROCHLORIDE 2-(3-(3-((2-Chloro-3-(trifluoromethyl)benzyl)(2,2-diphenylethyl)-amino)propoxy)phenyl)acetic a 2-(3-(3-((2-Chloro-3-(trifluoromethyl)benzyl)(2,2-diphenylethyl)-amino)propoxy)phenyl)acetic acid Benzeneacetic acid,3-[3-[[[2-chloro-3-(trifluoromethyl)phenyl]methyl](2,2-diphenylethyl)amino]propoxy]- 3-[3-[N-(2-CHLORO-3-TRIFLUOROMETHYLBENZYL)-(2,2-DIPHENYLETHYL)AMINO]PROPYLOXY]PHENYLACETIC ACID HYDROCHLORIDE 3-[3-[n-(2-chloro-3-trifluoroMethylbenzyl)-(2,2-diphenylethyl)aMino]propvloxy]phenylacetic acid hydrochloride 3-[3-[[[2-CHLORO-3-(TRIFLUOROMETHYL)PHENYL]METHYL](2,2-DIPHENYLETHYL)AMINO]PROPOXY]BENZENEACETIC ACID HYDROCHLORIDE
[Molecular Formula] C33H31ClF3NO3
[MDL Number] MFCD08276920
[MOL File] 405911-09-3.mol
[Molecular Weight] 582.05

Chemical Properties	Back Directory
[Melting point ] 174-179°C
[storage temp. ] Desiccate at RT
[solubility ] DMSO (Slightly), Methanol (Slightly)
[form ] Solid
[color ] White to Off-White

Safety Data	Back Directory
[Symbol(GHS) ] GHS05,GHS07
[Signal word ] Danger
[Hazard statements ] H302-H318-H413
[Precautionary statements ] P264-P270-P273-P280-P301+P312+P330-P305+P351+P338+P310-P501

Hazard Information	Back Directory
[Uses] GW3965 can be used in biological study of effect of liver X receptor agonists, T0901317 and GW3965 treatment on cholesterol efflux and apoptosis in human CAL-1 and GEN2.2 blastic plasmacytoid dendritic cell neoplasm cells.
[Definition] ChEBI: GW 3965 is a diarylmethane.
[Biological Activity] Selective, orally active non-steroidal agonist for the liver X receptor (LXR). In cell-based reporter gene assays, acts as a full agonist of hLXR α and hLXR β (EC 50 values are 190 and 30 nM respectively). Up-regulates ABCA1 gene expression and raises circulating HDL levels. Displays potent antiatherogenic activity in mouse models of atherosclerosis.
[target] LXRα

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