| Identification | More | [Name]
1-(2-Chlorophenyl)piperazine hydrochloride | [CAS]
41202-32-8 | [Synonyms]
1-(2-CHLOROPHENYL)PIPERAZINE HYDROCHLORIDE
1-(2-CHLOROPHENYL)PIPERAZINE MONOHYDROCHLORIDE
1-(O-CHLOROPHENYL)PIPERAZINE HYDROCHLORIDE
LABOTEST-BB LT00159499
LABOTEST-BB LT00454957
N-(2-CHLOROPHENYL)PIPERAZINE MONOHYDROCHLORIDE
TIMTEC-BB SBB003263
1-(2-chlorophenyl)piperazinium chloride
1-(2-CHLOROPHENYL)PIPERAZINE HCL
2-CHLOROPHENYLPIPERAZINE HYDROCHLORIDE
2-CHLOROPHENYL PIPERAZINE HCL
1-(2-CHLOROPHENYL)PIPERAZINE HYDROCHLORIDE 99% | [EINECS(EC#)]
255-262-0 | [Molecular Formula]
C10H14Cl2N2 | [MDL Number]
MFCD00012761 | [Molecular Weight]
233.14 | [MOL File]
41202-32-8.mol |
| Chemical Properties | Back Directory | [Melting point ]
160-163 °C (dec.)(lit.) | [storage temp. ]
Store at room temperature | [solubility ]
DMSO (Slightly), Methanol (Slightly) | [form ]
Solid | [color ]
White | [Sensitive ]
Hygroscopic | [BRN ]
5652889 | [InChI]
1S/C10H13ClN2.ClH/c11-9-3-1-2-4-10(9)13-7-5-12-6-8-13;/h1-4,12H,5-8H2;1H | [InChIKey]
GUTWDZXWTKMXPI-UHFFFAOYSA-N | [SMILES]
Cl[H].Clc1ccccc1N2CCNCC2 | [CAS DataBase Reference]
41202-32-8(CAS DataBase Reference) |
| Safety Data | Back Directory | [Risk Statements ]
R36/37/38:Irritating to eyes, respiratory system and skin . | [Safety Statements ]
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection . | [WGK Germany ]
3
| [Storage Class]
11 - Combustible Solids |
| Hazard Information | Back Directory | [Uses]
1-(2-Chlorophenyl)piperazine Hydrochloride is a reactant used in the preparation of piperazinyl, phenylpiperidinyl, tetrahydropyridinyl, and tetrahydropyridoindolylbutylbenzindoles with 5-hydroxytryptamine receptor antagonist activity. | [Synthesis]
To a stirred solution of tert-butyl 4-(2-chlorophenyl)piperazine-1-carboxylate (250 mg, 0.844 mmol) in 1,4-dioxane (2 mL) was added slowly and dropwise a 1,4-dioxane solution (0.9 mL, 3.60 mmol) in 4 N HCl at 0 °C. The reaction mixture was gradually warmed to room temperature and stirred continuously for 4 h (complete consumption of feedstock was confirmed by TLC monitoring). Upon completion of the reaction, the volatile solvent was removed under reduced pressure to give the crude product. The crude product was washed with ether (2 x 20 mL) and dried under high vacuum to yield 1-(2-chlorophenyl)piperazine hydrochloride (165 mg, 84% yield) as a white solid. | [References]
[1] Patent: WO2018/125961, 2018, A1. Location in patent: Page/Page column 45; 46 |
|
|