| Identification | Back Directory | [Name]
(-)-Pinoresinol 4-O-glucoside | [CAS]
41607-20-9 | [Synonyms]
(-)-pinoresinol glucoside
Pinoresinol beta-D-glucopyranoside
β-D-Glucopyranoside, (1R,3aS,4R,6aS)-2-methoxy-4-[tetrahydro-4-(4-hydroxy-3-methoxyphenyl)-1H,3H-furo[3,4-c]furan-1-yl]phenyl | [Molecular Formula]
C26H32O11 | [MDL Number]
MFCD28100584 | [MOL File]
41607-20-9.mol | [Molecular Weight]
520.53 |
| Hazard Information | Back Directory | [Uses]
(-)-Pinoresinol 4-O-glucoside ((-)-Pinoresinol 4-O-β-D-glucopyranoside) is a potent and orally active α-glucosidase inhibitor with an IC50 value of 48.13 μM. (-)-Pinoresinol 4-O-glucoside increases cell migration and early differentiation of pre-osteoblasts. (-)-Pinoresinol 4-O-glucoside increases protein level of BMP2, p-Smad1/5/8, RUNX2. (-)-Pinoresinol 4-O-glucoside attenuates oxidative stress, hyperglycemia and hepatic toxicity. (-)-Pinoresinol 4-O-glucoside has the potential for the research of osteoporosis and periodontal disease[1][2]. | [Definition]
ChEBI: (-)-Pinoresinol glucoside is a glycoside and a lignan. | [in vivo]
(-)-Pinoresinol 4-O-glucoside (50 mg/kg; p.o.; twenty days) attenuates oxidative stress, hyperglycaemia and hepatic toxicity in mice[2]. | Animal Model: | 27-30 g, Male Swiss albino mice[2] | | Dosage: | 50 mg/kg | | Administration: | P.o.; twenty days | | Result: | Exhibited a hepatoprotective activity in vivo as it lowered AST and ALT levels, caused a prominent decline in serum glucose level by 37.83% in streptozotocin-treated mice with promising elevation in insulin level of 25.37%. |
| [References]
[1] Park KR, et al. Effects of PIN on Osteoblast Differentiation and Matrix Mineralization through Runt-Related Transcription Factor. Int J Mol Sci. 2020 Dec 16;21(24):9579. DOI:10.3390/ijms21249579
[2] Youssef FS, et al. Pinoresinol-4-O-β-D-glucopyranoside: a lignan from prunes (Prunus domestica) attenuates oxidative stress, hyperglycaemia and hepatic toxicity in vitro and in vivo. J Pharm Pharmacol. 2020 Dec;72(12):1830-1839. DOI:10.1111/jphp.13358 |
|
| Company Name: |
BioBioPha Co., Ltd.
|
| Tel: |
0871-65217109 13211707573; |
| Website: |
http://www.biobiopha.com |
|