| Identification | Back Directory | [Name]
16,16-DIMETHYL PROSTAGLANDIN A2 | [CAS]
41691-92-3 | [Synonyms]
MOTPSJUHMGPRFZ-QEJIITRLSA-N
16,16-DIMETHYL PROSTAGLANDIN A2
9-OXO-15R-HYDROXY-16,16-DIMETHYL-PROSTA-5Z,10,13E-TRIEN-1-OIC ACID
Prosta-5,10,13-trien-1-oic acid, 15-hydroxy-16,16-dimethyl-9-oxo-, (5Z,13E,15R)- | [Molecular Formula]
C22H34O4 | [MDL Number]
MFCD00065727 | [MOL File]
41691-92-3.mol | [Molecular Weight]
362.5 |
| Chemical Properties | Back Directory | [Boiling point ]
526.9±50.0 °C(Predicted) | [density ]
1.078±0.06 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
DMF: >75 mg/ml (from PGA1); DMSO: >50 mg/ml (from PGA1); Ethanol: >100 mg/ml (from PGA1); PBS pH 7.2: >2.4 mg/ml (from PGA1) | [pka]
4.75±0.10(Predicted) |
| Hazard Information | Back Directory | [Description]
16,16-dimethyl PGA2 is a metabolism-resistant analog of PGA2 with a prolonged in vivo half-life. It inhibits the proliferation of Sendai virus in cultured African green monkey kidney cells by >90% at a concentration of 4 μg/ml. Daily infusion of 10 μg of 16,16-dimethyl PGA2 methyl ester into mice infected with influenza A virus increased survival by 40%. Similar treatment of mice inoculated with erythroleukemia cells delayed tumor growth and increased survival time. | [Uses]
16,16-dimethyl Prostaglandin A2 is a PGA2 analog studied for its antiproliferative properties. | [Definition]
ChEBI: 16,16-dimethyl-PGA2 is a prostanoid. | [storage]
Store at -20°C | [References]
[1] M. G. SANTORO. Prostaglandin A Compounds as Antiviral Agents[J]. Science, 1980, 209 4460. DOI: 10.1126/science.6157190
[2] M. G. SANTORO. Antiviral activity of a synthetic analog of prostaglandin A in mice infected with influenza A virus[J]. Archives of Virology, 1988, 99 1-2: 89-100. DOI: 10.1007/bf01311026
[3] S MARINI. Growth inhibition of Friend erythroleukaemia cell tumours in vivo by a synthetic analogue of prostaglandin A: an action independent of natural killer-activity[J]. British Journal of Cancer, 1990, 61 3: 394-399. DOI: 10.1038/bjc.1990.86 |
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BOC Sciences
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Energy Chemical
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