| Identification | Back Directory | [Name]
2-aminoadamantane-2-carboxylic acid | [CAS]
42381-05-5 | [Synonyms]
2-aminoadamantane-2-carboxylic acid
2-AMino-2-adaMantanecarboxylic acid
Tricyclo[3.3.1.13,7]decane-2-carboxylic acid, 2-amino- | [Molecular Formula]
C11H17NO2 | [MDL Number]
MFCD09264341 | [MOL File]
42381-05-5.mol | [Molecular Weight]
195.26 |
| Chemical Properties | Back Directory | [Boiling point ]
346.2±25.0 °C(Predicted) | [density ]
1.238±0.06 g/cm3(Predicted) | [storage temp. ]
Sealed in dry,Room Temperature | [form ]
Solid | [pka]
2.49±0.20(Predicted) | [color ]
Off-white to brown |
| Questions And Answer | Back Directory | [Uses]
Adamantanine is a γ-turn inducer for peptides. A potential cholecystokinin-B (CCK-B) receptor selective ligands. Also, it inhibits the transport of L-leucine and L-methionine into Ehrlich ascites cells. |
| Hazard Information | Back Directory | [Synthesis Reference(s)]
Journal of Medicinal Chemistry, 16, p. 823, 1973 DOI: 10.1021/jm00265a016 | [in vivo]
Adamantanine (500 mg/kg, i.p., single dose; 1000 mg/kg, p.o., single dose) is non-toxic in Sprague Dawley rats model as a a finely pulverized suspension[2]. | Animal Model: | Sprague-Dawley rats model[2] | | Dosage: | 500-1000 mg/kg | | Administration: | i.p., single dose; p.o., single dose | | Result: | Exhibited no toxicity. |
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