| Identification | More | [Name]
2,2-DIFLUOROETHYLAMINE | [CAS]
430-67-1 | [Synonyms]
uoroethyL
CF2HCH2NH2
AKOS B028561
TIMTEC-BB SBB009831
ART-CHEM-BB B028561
2,3-Difluoroethylamine
2,2-DIFLUOROETHYLAMINE
2,2-difluoroethanaMine
2,2-Difluoroethylamine>
2-Amino-1,1-difluoroethane
1-Amino-2,2-difluoroethane
Ethanamine,2,2-difluoro- (9CI)
2,2-Difluoroethylamine, 97%, for synthesis
2,2-DIFLUOROETHYLAMINE ISO 9001：2015 REACH | [EINECS(EC#)]
671-709-6 | [Molecular Formula]
C2H5F2N | [MDL Number]
MFCD00798137 | [Molecular Weight]
81.06 | [MOL File]
430-67-1.mol |
| Questions And Answer | Back Directory | [Preparation]
1.9 g (0.01 mol) CuI and 1.8 g (0.01 mol) D-glucosamine were added to a reactor containing N,N-dimethylformamide. 4.3 g (0.25 mol) liquid ammonia was introduced into the high-pressure reactor, and the temperature was raised to 90°C. 14.5 g (0.1 mol) 2,2-difluoro-1-chloroethane was then introduced into the high-pressure reactor at a molar ratio of 1:2.5 to liquid ammonia over 30 minutes. After the introduction was complete, the reactor was kept at the desired temperature for 3 hours. After the reaction was complete, the reactor was cooled, filtered, and excess ammonia was purged with nitrogen. The resulting product was then distilled to obtain 6.6 g (99% purity) of 2,2-difluoroethylamine. |
| Chemical Properties | Back Directory | [Boiling point ]
67.5-68.5 | [density ]
1,15 g/cm3 | [vapor pressure ]
14-56kPa at 20-50℃ | [refractive index ]
1.3410-1.3450 | [form ]
clear liquid | [pka]
7.09±0.30(Predicted) | [color ]
Colorless to Yellow | [InChI]
InChI=1S/C2H5F2N/c3-2(4)1-5/h2H,1,5H2 | [InChIKey]
OVRWUZYZECPJOB-UHFFFAOYSA-N | [SMILES]
C(N)C(F)F | [CAS DataBase Reference]
430-67-1(CAS DataBase Reference) |
| Hazard Information | Back Directory | [Chemical Properties]
Liquid | [Uses]
2,2-Difluoroethylamine (DFEA) is an ESI-compatible buffering reagent whose conjugate acid has a pKa of 7.2, providing buffering capacity at physiological pH[1]. 2,2-Difluoroethylamine serves as a nucleophile in Ni-catalyzed C–N cross-couplings with aryl electrophiles, including N-arylation of fluoroalkylamines and competition studies against other heteroatom-containing nucleophiles[2]. | [References]
[1]Davis, B. T. V., Velyvis, A., & Vahidi, S. (2023). Fluorinated Ethylamines as Electrospray-Compatible Neutral pH Buffers for Native Mass Spectrometry. Analytical Chemistry, 95(48), 17525–17532. https://doi.org/10.1021/acs.analchem.3c02640
[2]McGuire, R. T., Yadav, A. A., & Stradiotto, M. (2020). Nickel‐Catalyzed N‐Arylation of Fluoroalkylamines. Angewandte Chemie International Edition, 60(8), 4080–4084. https://doi.org/10.1002/anie.202014340 |
|
| Company Name: |
SHANG FLUORO Gold
|
| Telephone: |
021-65170832 15601903708 |
| Website: |
http://www.shangfluoro.com |
| Company Name: |
J & K SCIENTIFIC LTD.
|
| Telephone: |
18210857532 18210857532 |
| Website: |
https://www.jkchemical.com |
| Company Name: |
Energy Chemical
|
| Telephone: |
400-0056266 |
| Website: |
www.energy-chemical.com |
| Company Name: |
Jia Xing Isenchem Co.,Ltd
|
| Telephone: |
0573-85285100 18627885956 |
| Website: |
https://www.chemicalbook.com/ShowSupplierProductsList14265/0_EN.htm |
|