| Identification | More | [Name]
2,2,2-TRIFLUOROETHYLAMINE | [CAS]
753-90-2 | [Synonyms]
2,2,2-TRIFLUOROETHANAMINE
2,2,2-TRIFLUOROETHYLAMINE
2-AMINO-1,1,1-TRIFLUOROETHANE
AURORA KA-7828
RARECHEM AL BW 0451
2,2,2-trifluoro-ethanamin
2,2,2-trifluoro-ethylamin
beta,beta,beta-Trifluoroethylamine
CF3CH2NH2
Ethanamine, 2,2,2-trifluoro-
Ethylamine, 2,2,2-trifluoro-
Trifluoroethylamine
2,2,2-TRIFLUOROETHYLAMINE, 99.5%
2,2,2-Trifluoroethylamine,98%
2,2,2-Trifluoroethylamine, 99.50%
2,2,2-Trifluoroethylamine99% | [EINECS(EC#)]
212-041-3 | [Molecular Formula]
C2H4F3N | [MDL Number]
MFCD00008132 | [Molecular Weight]
99.06 | [MOL File]
753-90-2.mol |
| Questions And Answer | Back Directory | [Synthesis]
2,2,2-Trifluoroethylamine can be prepared by the following steps: In a glove box, ruthenium catalyst (5 mol%, 15.2 mg, 0.025 mmol), trifluoromethylformamide (0.50 mmol, 1 equiv), and pinacolborane (2.0 mmol, 4 equiv) are added to a 25 mL Schlenk flask equipped with a magnetic stir bar. The resulting reaction mixture is stirred in an oil bath at 80 °C for 24 h. The reaction progress is monitored by TLC. After the reaction is completed, the reactants are separated by column chromatography to obtain the final product. Figure 2. Synthetic route of 2,2,2-trifluoroethylamine. |
| Chemical Properties | Back Directory | [Appearance]
clear colorless liquid | [Boiling point ]
36-37 °C(lit.)
| [density ]
1.262 g/mL at 20 °C(lit.)
| [vapor pressure ]
~7.6 psi ( 20 °C)
| [refractive index ]
n20/D 1.301(lit.)
| [Fp ]
2 °F
| [storage temp. ]
2-8°C
| [form ]
Liquid | [pka]
5.47±0.30(Predicted) | [color ]
Clear colorless | [Specific Gravity]
1.245 | [Detection Methods]
GC | [BRN ]
1733204 | [InChI]
InChI=1S/C2H4F3N/c3-2(4,5)1-6/h1,6H2 | [InChIKey]
KIPSRYDSZQRPEA-UHFFFAOYSA-N | [SMILES]
C(N)C(F)(F)F | [CAS DataBase Reference]
753-90-2(CAS DataBase Reference) | [NIST Chemistry Reference]
2,2,2-Trifluoroethylamine(753-90-2) | [Storage Precautions]
Store under nitrogen | [EPA Substance Registry System]
753-90-2(EPA Substance) |
| Safety Data | Back Directory | [Symbol(GHS) ]
  
GHS02,GHS05,GHS07 | [Signal word ]
Danger | [Hazard statements ]
H225-H302-H314-H412 | [Precautionary statements ]
P210-P273-P280-P301+P312-P303+P361+P353-P305+P351+P338 | [Hazard Codes ]
F,C,T,Xi | [Risk Statements ]
R11:Highly Flammable.
R34:Causes burns. | [Safety Statements ]
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection .
S45:In case of accident or if you feel unwell, seek medical advice immediately (show label where possible) .
S25:Avoid contact with eyes .
S16:Keep away from sources of ignition-No smoking . | [RIDADR ]
UN 2733 3/PG 2
| [WGK Germany ]
3
| [RTECS ]
KS0175000
| [F ]
3-10-13 | [Hazard Note ]
Corrosive/Toxic/Flammable | [TSCA ]
T | [REACH Registrations]
Active | [HazardClass ]
3 | [PackingGroup ]
II | [HS Code ]
29211990 | [Storage Class]
3 - Flammable liquids | [Hazard Classifications]
Acute Tox. 4 Oral
Aquatic Chronic 3
Flam. Liq. 2
Skin Corr. 1B | [Toxicity]
LC50 ihl-mus: 4170 mg/m3/2H 85JCAE -,606,86 |
| Raw materials And Preparation Products | Back Directory | [Raw materials]
Sodium hydroxide-->Hydrochloric acid-->Diethyl ether-->Lithium Aluminum Hydride-->Trifluoroacetamide-->BIS(2,2,2-TRIFLUOROETHYL)AMINE-->Trifluoroacetonitrile | [Preparation Products]
2-CHLORO-1,1,1-TRIFLUOROETHANE-->2-chloro-N-(2,2,2-trifluoroethyl)acetamide-->Benzenamine, 3-methoxy-N-(2,2,2-trifluoroethyl)--->Carbamic acid, (2,2,2-trifluoroethyl)-, 1,1-dimethylethyl ester (9CI)-->2,2,2-Trifluoroethylamine hydrochloride-->4-bromo-N-(2,2,2-trifluoroethyl)aniline |
| Hazard Information | Back Directory | [Chemical Properties]
clear colorless liquid | [Uses]
2,2,2-Trifluoroethanamine is a reagent used in chemical synthesis. | [Synthesis Reference(s)]
Canadian Journal of Chemistry, 32, p. 639, 1954 DOI: 10.1139/v54-083 | [General Description]
2,2,2-Trifluoroethylamine, a volatile organic compound, was tested using corona discharge ion mobility spectrometry with orthogonal acceleration time of flight mass spectrometry (CD IMS-oaTOF). | [Safety Profile]
Low toxicity by inhalation.Corrosive. Highly flammable liquid. When heated todecomposition it emits very toxic fumes of F?? and NOx. |
| Spectrum Detail | Back Directory | [Spectrum Detail]
2,2,2-TRIFLUOROETHYLAMINE(753-90-2)MS
2,2,2-TRIFLUOROETHYLAMINE(753-90-2)1HNMR
2,2,2-TRIFLUOROETHYLAMINE(753-90-2)13CNMR
2,2,2-TRIFLUOROETHYLAMINE(753-90-2)IR1
2,2,2-TRIFLUOROETHYLAMINE(753-90-2)Raman
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