| Identification | More | [Name]
2-Amino-6-fluorobenzoic acid | [CAS]
434-76-4 | [Synonyms]
2-AMINO-6-FLUOROBENZOIC ACID
6-FLUOROANTHRANILIC ACID
BUTTPARK 44\01-59
RARECHEM AL BO 0279
TIMTEC-BB SBB006549
2-fluoro-6-aminobenzoic acid
TRIPHENYLBORANE, 0.25M SOLUTION IN TETRA
2-AMINO-6-FLUOROBENZOIC ACID (6-FLUOROANTHRANILIC ACID)
2-Amino-6-fluorobenzoic acid, 98% (6-Fluoroanthranilic acid)
2-Amino-6-Fluorobenzoic
2-Amino-6-fluorobenzoic acid 97%
2-Amino-6-fluorobenzoicacid97% | [EINECS(EC#)]
627-707-2 | [Molecular Formula]
C7H6FNO2 | [MDL Number]
MFCD00067781 | [Molecular Weight]
155.13 | [MOL File]
434-76-4.mol |
| Chemical Properties | Back Directory | [Appearance]
white to light yellow crystal powder | [Melting point ]
167-169 °C (lit.) | [Boiling point ]
223.67°C (rough estimate) | [density ]
1.3021 (estimate) | [storage temp. ]
Keep in dark place,Inert atmosphere,Room temperature | [solubility ]
soluble in Methanol | [form ]
Crystalline Powder | [pka]
4.01±0.10(Predicted) | [color ]
Yellow to brown | [BRN ]
3540926 | [InChIKey]
RWSFZKWMVWPDGZ-UHFFFAOYSA-N | [CAS DataBase Reference]
434-76-4(CAS DataBase Reference) | [NIST Chemistry Reference]
Anthralic acid, 6-fluoro-(434-76-4) |
| Safety Data | Back Directory | [Hazard Codes ]
Xi | [Risk Statements ]
R36/37/38:Irritating to eyes, respiratory system and skin . | [Safety Statements ]
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S36:Wear suitable protective clothing .
S37/39:Wear suitable gloves and eye/face protection . | [WGK Germany ]
3
| [Hazard Note ]
Irritant | [HazardClass ]
IRRITANT | [HS Code ]
29224999 |
| Hazard Information | Back Directory | [Chemical Properties]
white to light yellow crystal powder | [Uses]
Used in the synthesis of a novel benzamide with potent neuroleptic activity. 5- fluoro-2-methyl-3,l-benzoxazin-4-one was obtained from 2-amino-6-fluorobenzoic acid. The condensation of 2-amino-6-fluorobenzoic acid methyl ester and (4-fluorophenyl) acetyl chloride with N,N-dimethylamino-4-pyridine in CH 2 Cl 2 to give 2-fluoro-6-[2-(4-fluoro-phenyl)-acetylamino]-benzoic acid methyl ester in 61% yield. 2 Amino 6 fluorobenzoic acid is another easily ac cessible synthon for construction of monofluorinated heterocycles. Reactions of 2,3,4,6-tetra-O-acetyl-n-D_glucopyranosyl bromide (2) with p-hydroxybenzaldehyde, trifluoromethyl and fluoro substi- tuted aniline and 2-amino-6-fluorobenzoic acid gave lO-(Pformyl- pheny1)-2,3,4,6-tetra-O-acetyl-(3-D-glucopyranoside. 2-Fluoro-6-iodobenzoic acid,a loose white crystal,was synthesized by using 2-amino-6-fluorobenzoic acid as the starting material. | [Definition]
ChEBI: 2-Amino-6-fluorobenzoic acid is an aminobenzoic acid. | [storage]
Store in cool place. Keep container tightly closed in a dry and well-ventilated place. Store away from strong oxidizing agents. | [Synthesis]
The synthesis of 2-Amino-6-fluorobenzoic acid is as follows:
A 50 ml three-necked flask was charged with 1.85 g (10 mmol) of 6-fluoro-2-nitrobenzoic acid, 25.6 mg (0.2 mmol) of molybdenum dioxide, and 76.8 mg of activated carbon. 30 ml of absolute ethanol was added dropwise 1.25 g (20 mmol) of hydrazine hydrate (80%) at room temperature. After the reaction was completed at room temperature for 7 h, TLC monitoring showed that the reaction was completed, filtered, and the filtrate was concentrated, then ethyl acetate (20 mL) and water (10 ml) were added and extracted. The organic phase was washed with water and concentrated to give 1.5g desired product as a pale yellow solid, yield 96.8%, HPLC purity 99.6%.
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