| Identification | Back Directory | [Name]
4-(4-AMINOPHENYL)MORPHOLIN-3-ONE | [CAS]
438056-69-0 | [Synonyms]
Rivaroxaban Impurity 37
Rivaroxaban InterMediate
Rivaroxaban Intermediate 1
4-(4-aMinophenyl) Morpholinone
4-(3-Oxo-4-Morpholinyl)aniline
4-(4-AMinophenyl)Morpholin-3-1
4-(-4-amino phenyl0-3-Morpholine
4-(4-AMinophenyl)-3-Morpholinone
4-(4-AMINOPHENYL)MORPHOLIN-3-ONE
4-(3-Oxo-4-Morpholinyl)aniline-d4
4-(4-AMinophlenyl)Morpholin-3-one
3-Morpholinone, 4-(4-aminophenyl)-
4-(4-Aminophenyl)morpholin-3-one ,97%
4-(4-aMinophenyl)Morpholine-3- ketone
4-(4-AMinophenyl)Morpholin-3-one(For Rivaroxaban) | [EINECS(EC#)]
1308068-626-2 | [Molecular Formula]
C10H12N2O2 | [MDL Number]
MFCD08236742 | [MOL File]
438056-69-0.mol | [Molecular Weight]
192.21 |
| Chemical Properties | Back Directory | [Melting point ]
171.0 to 175.0 °C | [Boiling point ]
502.3±45.0 °C(Predicted) | [density ]
1.268 | [vapor pressure ]
0Pa at 25℃ | [storage temp. ]
Keep in dark place,Inert atmosphere,Room temperature | [solubility ]
DMSO (Slightly), Methanol (Slightly, Heated) | [form ]
Solid | [pka]
4.85±0.10(Predicted) | [color ]
White to Light Brown | [Water Solubility ]
16.6g/L at 20℃ | [Major Application]
pharmaceutical | [InChI]
InChI=1S/C10H12N2O2/c11-8-1-3-9(4-2-8)12-5-6-14-7-10(12)13/h1-4H,5-7,11H2 | [InChIKey]
MHCRLDZZHOVFEE-UHFFFAOYSA-N | [SMILES]
N1(C2=CC=C(N)C=C2)CCOCC1=O | [LogP]
-0.8 at 25℃ | [CAS DataBase Reference]
438056-69-0 |
| Hazard Information | Back Directory | [Chemical Properties]
Off-White Solid | [Uses]
Reagent used in the preparation of various Morpholine based pharmaceuticals. | [Uses]
Rivaroxaban intermediate | [Flammability and Explosibility]
Nonflammable | [Synthesis]
2-anilinoethanol (11) was condensed with ethyl chloroacetate in the presence of potassium tert-butoxide in tetrahydrofuran to afford the required phenylmorpholinone (12). Nitration of the intermediate morpholinone (12) in a solution of concentrated sulphuric acid with nitric acid below room temperature provided after recrystallization the para-product (13) in > 99.5% HPLC purity. The mother liquor was enriched predominantly with unwanted ortho - and meta-isomers together with depleted para-product. By subsequent hydrogenation of the nitro group in 13 with palladium on charcoal in methanol the 4-(4-Aminophenyl)morpholin-3-one (14) was obtained.
[1] W. MEDERSKI Markus W P Wendel. Practical and efficient processes for the preparation of 4-(4-aminophenyl)morpholin-3-ones on a larger scale: precursor of factor Xa inhibitors[J]. Heterocycles, 2007, 74 1: 437-445. DOI:10.3987/COM-07-S(W)22.
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