| Identification | More | [Name]
4-Nitrobenzyl chloroformate | [CAS]
4457-32-3 | [Synonyms]
4-NITROBENZYL CHLOROCARBONATE
4-NITROBENZYL CHLOROFORMATE
4-NITROCARBOBENZOXYCHLORIDE
CHLOROFORMIC ACID 4-NITROBENZYL ESTER
PARA-NITROBENZYL CHLOROFORMATE
PNBCF
P-NITROBENZYL CHLOROFORMATE
P-NITROCARBOBENZOXY CHLORIDE
4-Nitrobenzyl chloridocarbonate
4-Nitrobenzyloxycarbonyl chloride
carbonochloridicacid,(4-nitrophenyl)methylester
Chloroformic acid p-nitrobenzyl ester
Formic acid, chloro-, p-nitrobenzyl ester
p-Nitrobenzyloxycarbonyl chloride
4-Nitrobenzylchloroformate,95%
P-Nitrobenzyl
4-Nitrobenzyl chloroformate 98%
4-Nitorobenzyl chloroformate
CHLOROFORMIC ACID 4-NITROBENYL ESTER
Chloridocarbonic acid (4-nitrophenyl)methyl ester | [EINECS(EC#)]
224-708-6 | [Molecular Formula]
C8H6ClNO4 | [MDL Number]
MFCD00007375 | [Molecular Weight]
215.59 | [MOL File]
4457-32-3.mol |
| Chemical Properties | Back Directory | [Appearance]
off-white to pale yellow powder | [Melting point ]
32-34 °C(lit.) | [Boiling point ]
230°C 10mm | [density ]
1.4928 (rough estimate) | [refractive index ]
1.552-1.556
| [Fp ]
>230 °F
| [storage temp. ]
2-8°C
| [solubility ]
Acetonitrile (Slightly), Chloroform (Slightly) | [form ]
powder to crystal | [color ]
White to Light yellow | [Stability:]
Stable, but moisture-sensitive. May develop pressure in storage. Incompatible with moisture, strong bases, alcohols, amines, acids. | [Sensitive ]
Moisture Sensitive | [BRN ]
912446 | [Major Application]
peptide synthesis | [InChI]
1S/C8H6ClNO4/c9-8(11)14-5-6-1-3-7(4-2-6)10(12)13/h1-4H,5H2 | [InChIKey]
MHSGOABISYIYKP-UHFFFAOYSA-N | [SMILES]
[O-][N+](=O)c1ccc(COC(Cl)=O)cc1 | [CAS DataBase Reference]
4457-32-3(CAS DataBase Reference) | [NIST Chemistry Reference]
Carbonochloridic acid, (4-nitrophenyl)methyl ester(4457-32-3) | [EPA Substance Registry System]
4457-32-3(EPA Substance) |
| Safety Data | Back Directory | [Hazard Codes ]
C,T | [Risk Statements ]
R34:Causes burns.
R37:Irritating to the respiratory system.
R23/24/25:Toxic by inhalation, in contact with skin and if swallowed .
R36/37:Irritating to eyes and respiratory system . | [Safety Statements ]
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection .
S45:In case of accident or if you feel unwell, seek medical advice immediately (show label where possible) .
S38:In case of insufficient ventilation, wear suitable respiratory equipment .
S27:Take off immediately all contaminated clothing . | [RIDADR ]
UN 3261 8/PG 2
| [WGK Germany ]
3
| [F ]
3-4.9 | [Hazard Note ]
Corrosive/Toxic/Moisture Sensitive | [TSCA ]
TSCA listed | [HazardClass ]
8 | [PackingGroup ]
III | [HS Code ]
29159000 | [Storage Class]
8A - Combustible corrosive hazardous materials | [Hazard Classifications]
Eye Dam. 1
Skin Corr. 1B
STOT SE 3 |
| Hazard Information | Back Directory | [Chemical Properties]
off-white to pale yellow powder | [Uses]
4-Nitrobenzyl Chloroformate is used in the preparation of prodrugs of cytotoxic acridines used in conjunction with enzyme prodrugs which counter carcinoma cells. | [reaction suitability]
reaction type: Carbonylations |
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