| Identification | More | [Name]
2-Bromo-5-nitropyridine | [CAS]
4487-59-6 | [Synonyms]
2-BROMO-5-NITROPYRIDINE
TIMTEC-BB SBB003519
2-BROMO-5-NITROPYRIDINE 97%
2-BROMO-5-NITROPYRIDINE 2-BROMO-5-NITROPYRIDINE
2-BORMO-5-NITROPYRIDINE | [EINECS(EC#)]
224-777-2 | [Molecular Formula]
C5H3BrN2O2 | [MDL Number]
MFCD00006222 | [Molecular Weight]
202.99 | [MOL File]
4487-59-6.mol |
| Questions And Answer | Back Directory | [Synthesis]
A mixture of 1.53 g (10.94 mmol) of 2-hydroxy-5-nitropyridine, 4.1 g (12.71 mmol) of tetrabutylammonium bromide, and 3.71 g (26.1 mmol) of P2O5 in 29 ml of benzene was heated and stirred under reflux for 1 hour. The mixture was cooled to room temperature, the upper layer was separated by decantation, and the lower layer was ground with benzene (3 × 6 ml). The extract was combined with the organic phase, washed with saturated solutions of NaHCO3 and NaCl, and dried over MgSO4. The solvent was distilled off under reduced pressure, and the residue was recrystallized from petroleum ether. Yield: 1.7 g (48%). Mp: 138-139°C (bp: 40-70°C). |
| Chemical Properties | Back Directory | [Appearance]
Off-white to light yellow crystal. | [Melting point ]
139-141 °C (lit.) | [Boiling point ]
145-147 °C/10 mmHg (lit.) | [density ]
1.8727 (rough estimate) | [refractive index ]
1.6200 (estimate) | [Fp ]
145-147°C/10mm | [storage temp. ]
Keep Cold | [solubility ]
Chloroform, Hot Methanol | [form ]
Crystalline Powder | [pka]
-3.24±0.10(Predicted) | [color ]
Light yellow to light brown | [Water Solubility ]
Insoluble in water. | [Detection Methods]
HPLC | [BRN ]
120901 | [InChI]
InChI=1S/C5H3BrN2O2/c6-5-2-1-4(3-7-5)8(9)10/h1-3H | [InChIKey]
HUUFTVUBFFESEN-UHFFFAOYSA-N | [SMILES]
C1(Br)=NC=C([N+]([O-])=O)C=C1 | [CAS DataBase Reference]
4487-59-6(CAS DataBase Reference) |
| Safety Data | Back Directory | [Hazard Codes ]
Xn,Xi | [Risk Statements ]
R22:Harmful if swallowed.
R36/37/38:Irritating to eyes, respiratory system and skin .
R20/21/22:Harmful by inhalation, in contact with skin and if swallowed . | [Safety Statements ]
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S37/39:Wear suitable gloves and eye/face protection .
S22:Do not breathe dust .
S36:Wear suitable protective clothing . | [RIDADR ]
UN 2811 6.1/PG 3
| [WGK Germany ]
3
| [Hazard Note ]
Irritant/Keep Cold | [HazardClass ]
IRRITANT, IRRITANT-HARMFUL | [PackingGroup ]
III | [HS Code ]
29333990 | [Storage Class]
6.1C - Combustible acute toxic Cat.3
toxic compounds or compounds which causing chronic effects | [Hazard Classifications]
Acute Tox. 3 Oral
Eye Irrit. 2
Skin Irrit. 2
STOT SE 3 |
| Hazard Information | Back Directory | [Chemical Properties]
Off-white to light yellow crystal. | [Uses]
2-Bromo-5-nitropyridine was used in preparation of boc-protected (piperazin-1-ylmethyl)biaryls via microwave-mediated Suzuki-Miyaura coupling with (boc-piperazin-1-ylmethyl)phenylboronic acid pinacol esters. It was also used in the synthesis of 2-pyridyl analogs. | [Uses]
2-Bromo-5-nitropyridine was used in preparation of boc-protected (piperazin-1-ylmethyl)biaryls via microwave-mediated Suzuki-Miyaura coupling with (boc-piperazin-1-ylmethyl)phenylboronic acid pinacol esters. It was also used in the synthesis of 2-pyridyl analogs. Substituted 5-nitro-2-ethynylpyridines were synthesized by the Sonogashira reaction of 2-bromo-5-5-nitropyridine with terminal acetylenes. |
|
| Company Name: |
J & K SCIENTIFIC LTD.
|
| Telephone: |
18210857532 18210857532 |
| Website: |
https://www.jkchemical.com |
| Company Name: |
Alfa Aesar
|
| Telephone: |
400-6106006 |
| Website: |
http://chemicals.thermofisher.cn |
| Company Name: |
Energy Chemical
|
| Telephone: |
400-0056266 |
| Website: |
www.energy-chemical.com |
|