| Identification | More | [Name]
L-Lactide | [CAS]
4511-42-6 | [Synonyms]
(3S,6S)-(-)-3,6-DIMETHYL-1,4-DIOXANE-2,5-DIONE
(3S)-CIS-3,6-DIMETHYL-1,4-DIOXANE-2,5-DIONE
LACTIDE
LACTIDE(L-)
L-(-)-DILACTIDE
L-(-)-LACTIDE
L-LACTIDE
L-LACTIDE S
PURASORB(R) L
5-dione,3,6-dimethyl-,(3s,6s)-4-dioxane-2
(S,S)-3,6-Dimethyl-1,4-dioxane-2,5-dione
L-(-)-LACTIDE 98+%
3,6-Dimethyl-2,5-p-dioxanedione
L-3,6-Dimethyl-1,4-dioxane-2,5-dione
1,4-Dioxane-2,5-dione, 3,6-dimethyl-, (3S,6S)- | [EINECS(EC#)]
224-832-0 | [Molecular Formula]
C6H8O4 | [MDL Number]
MFCD00070594 | [Molecular Weight]
144.13 | [MOL File]
4511-42-6.mol |
| Chemical Properties | Back Directory | [Melting point ]
92-94 °C(lit.)
| [Boiling point ]
255°C | [density ]
1.186±0.06 g/cm3(Predicted) | [vapor pressure ]
0.311Pa at 25℃ | [refractive index ]
1.4475 | [storage temp. ]
2-8°C | [solubility ]
Soluble in chloroform, and methanol. Slightly soluble in benzene. | [form ]
Solid | [color ]
White to Off-White | [optical activity]
[α]20/D 285°, c = 1 in toluene | [Water Solubility ]
16.7g/L at 20℃ | [Sensitive ]
Moisture Sensitive | [BRN ]
82124 | [Stability:]
Hygroscopic | [InChIKey]
JJTUDXZGHPGLLC-IMJSIDKUSA-N | [LogP]
0.4 at 25℃ | [CAS DataBase Reference]
4511-42-6(CAS DataBase Reference) | [EPA Substance Registry System]
4511-42-6(EPA Substance) |
| Safety Data | Back Directory | [Hazard Codes ]
Xi | [Risk Statements ]
R36/37/38:Irritating to eyes, respiratory system and skin . | [Safety Statements ]
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S37/39:Wear suitable gloves and eye/face protection . | [WGK Germany ]
3
| [TSCA ]
Yes | [HS Code ]
29322090 |
| Hazard Information | Back Directory | [Description]
L-lactide (4511-42-6) is a cyclic lactone that is derived from lactic acid. It has the molecular formula C3H6O2 and is an essential building block for synthesizing polylactic acid (PLA) plastics, which are widely used in the manufacturing industry.
| [Chemical Properties]
White crystal | [Uses]
(3S)-cis-3,6-Dimethyl-1,4-dioxane-2,5-dione may be used in the synthesis of optically active terpyridine containing poly(L-lactide)s, polydisperse lactic acid oligomers, bicyclic and tricyclic lactide derivatives. | [Application]
L-Lactide is a monomer used to produce polylactic acid (PLA), which is a biodegradable thermoplastic that has many uses in the pharmaceutical industry. Additionally, L-Lactide can be used to modify existing drug carriers or create new ones from scratch. As such, the pharmaceutical industry relies heavily on L-Lactide for its versatile applications. | [Flammability and Explosibility]
Nonflammable | [Purification Methods]
This is the cyclic dilactone of lactic acid. The (±)-cis-racemate has been distilled with b 142o/8mm; the distillate which solidifies gives yellow needles on recrystallisation from EtOH with m 128o, from Et2O with m 129o, or CHCl3 with m 126o , 1720-1740 cm-1. It hydrolyses in cold max H2O. [Carothers et al. J Am Chem Soc 54 772 1932]. A trans-form (probably RS,SR) has been reported which crystallises from Et2O with m 42-43o [Hummel et al. Acta Cryst (Sect B) 38 1679 1982]. The R,R -(+)-lactide has b 150o/2mm and crystallises from Et2O with m 95o , or m 96.5 -97.5o (from CHCl3) or m 97.7o (from EtOAc) and [] D +297o (c 1.2, *C6H6). The S,S-(-)-lactide has b 150o/2.5mm and crystallises from EtOAc with m 98.7o, or m 95o (from CHCl3) or m 96.5-97.5o (from CCl4) and []D -297o (c 1.2, *C6H6). [Toniolo et al. J Org Chem 35 6 1970, Beilstein 19 H 154, 19 I 179, 19 II 176, 19 IV 1927, 19/5 V 10.] |
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