| Identification | Back Directory | [Name]
BOC-VAL-GLY-OH | [CAS]
45233-75-8 | [Synonyms]
Boc-Val-Gly
BOC-VAL-GLY-OH
Boc-L-Val-Gly-OH
Boc-Val-Gly-OH≥ 95% (HPLC)
(Tert-Butoxy)Carbonyl Val-Gly-OH
Butoxycarbonyl L-valinyl-glycine
(tert-Butoxycarbonyl)-L-valylglycine
Glycine, N-[(1,1-dimethylethoxy)carbonyl]-L-valyl-
(S)-2-(2-((tert-Butoxycarbonyl)amino)-3-methylbutanamido)aceticacid
2-[(2S)-2-{[(tert-butoxy)carbonyl]amino}-3-methylbutanamido]acetic acid | [Molecular Formula]
C12H22N2O5 | [MDL Number]
MFCD00134861 | [MOL File]
45233-75-8.mol | [Molecular Weight]
274.31 |
| Chemical Properties | Back Directory | [Melting point ]
100-110°C | [Boiling point ]
491.2±30.0 °C(Predicted) | [density ]
1.141±0.06 g/cm3(Predicted) | [storage temp. ]
2-8°C | [form ]
Solid | [pka]
3.40±0.10(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Chemical Properties]
White powder | [Uses]
peptide synthesis | [reaction suitability]
reaction type: Boc solid-phase peptide synthesis | [Synthesis]
GENERAL METHOD: Methyl tert-butoxycarbonyl-L-valylaminoacetate (2.6 g, 10 mmol) was dissolved in 50 mL of methanol, 1 M NaOH solution (30 mL) was added, and the reaction was stirred for 3 h at room temperature. Upon completion of the reaction, the solvent was removed by vacuum evaporation and the residue was adjusted to pH 2-3 with 1 M HCl. Subsequently, the mixture was extracted three times with EtOAc, the organic phases were combined and dried with anhydrous Na2SO4. Finally, the EtOAc was evaporated to afford the target compound 10a as a white solid in 92.4% yield. | [References]
[1] Journal of the American Chemical Society, 2010, vol. 132, # 13, p. 4577 - 4579
[2] Bioorganic and Medicinal Chemistry, 2014, vol. 22, # 11, p. 3055 - 3064
[3] Journal of the Chemical Society, Perkin Transactions 2: Physical Organic Chemistry (1972-1999), 1992, # 7, p. 1187 - 1193
[4] Journal of Medicinal Chemistry, 1995, vol. 38, # 20, p. 4014 - 4018 |
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