| Identification | Back Directory | [Name]
4-Methoxy-3-methylphenyl piperidin-1-yl sulphone, 2-Methyl-4-[(piperidin-1-yl)sulphonyl]anisole | [CAS]
457961-34-1 | [Synonyms]
Cy1001
AA92593
AA92593 >=98% (HPLC)
1-(4-Methoxy-3-methyl-benzenesulfonyl)-piperidine
1-[(4-Methoxy-3-methylphenyl)sulphonyl]piperidine
Piperidine, 1-[(4-methoxy-3-methylphenyl)sulfonyl]-
4-Methoxy-3-methylphenyl piperidin-1-yl sulphone, 2-Methyl-4-[(piperidin-1-yl)sulphonyl]anisole | [Molecular Formula]
C13H19NO3S | [MOL File]
457961-34-1.mol | [Molecular Weight]
269.36 |
| Chemical Properties | Back Directory | [storage temp. ]
-20°C | [solubility ]
DMSO: soluble10mg/mL, clear | [form ]
powder | [color ]
white to beige | [InChI]
1S/C13H19NO3S/c1-11-10-12(6-7-13(11)17-2)18(15,16)14-8-4-3-5-9-14/h6-7,10H,3-5,8-9H2,1-2H3 | [InChIKey]
HDTKLZINZGEPFG-UHFFFAOYSA-N | [SMILES]
[S](=O)(=O)(N2CCCCC2)c1cc(c(cc1)OC)C |
| Hazard Information | Back Directory | [Uses]
AA92593 has been used as a selective melanopsin inhibitor. | [Biochem/physiol Actions]
AA92593 is an opsinamide, a potent antagonist of melanopsin-mediated phototransduction with an IC50 of 665 nM in a Ca2+ flux assay in CHO cells expressing melanopsin (Opn4) and selectivity > 10 μM at 74 common biological targets. AA41612 is believed to act by competing for binding to melanopsin. AA41612 inhibited mouse pupillary light reflex and light aversion in vivo. AA92593 and similar compounds might be useful in alleviating the photophobia associated with migraine. | [in vivo]
AA92593 is able to decrease IOP in rabbits living under normal light condition[2].
AA92593 produces an increment in melatonin levels resulting in a drop of IOP[2].
| Animal Model: | Wild type (WT) mice[4]. | | Dosage: | 30 mg/kg. | | Administration: | IP 20 min prior to PLR measurement. | | Result: | Attenuated pupil constriction in response to light (1013 ph.cm?2.s?1) by ~50%. |
| [storage]
Store at -20°C |
|
| Company Name: |
Sigma-Aldrich
|
| Telephone: |
021-61415566 800-8193336 |
| Website: |
https://www.sigmaaldrich.cn |
| Company Name: |
Lynnchem
|
| Telephone: |
86-(0)29-85992781 17792393971 |
| Website: |
http://www.lynnchem.com/ |
| Company Name: |
Energy Chemical
|
| Telephone: |
021-58432009 400-005-6266 |
| Website: |
http://www.energy-chemical.com |
| Company Name: |
cjbscvictory
|
| Telephone: |
13348960310 13348960310 |
| Website: |
www.weikeqi-biotech.com/ |
|