| Identification | Back Directory | [Name]
O-(4-hydroxy-3-iodophenyl)-3-iodo-L-tyrosine | [CAS]
4604-41-5 | [Synonyms]
3,3'-L-Diiodothyronine
3,3'-Diiodo-L-thyronine
Levothyroxine Impurity 13
Levothyroxine EP Impurity J
3,5-Diiodo-L-tyrosinedihydrae
3-Iodo-O-(4-hydroxy-3-iodophenyl)-L-tyrosine
O-(3-Iodo-4-hydroxyphenyl)-3-iodo-L-tyrosine
O-(4-hydroxy-3-iodophenyl)-3-iodo-L-tyrosine
L-Tyrosine,O-(4-hydroxy-3-iodophenyl)-3-iodo-
3-[4-(4-Hydroxy-3-iodophenoxy)-3-iodophenyl]-L-alanine
(S)-α-Amino-4-[(4-hydroxy-3-iodophenyl)oxy]-3-iodobenzenepropanoic acid
(2S)-2-amino-3-[4-(4-hydroxy-3-iodophenoxy)-3-iodophenyl]propanoic acid
(2S)-2-amino-3-[4-(4-hydroxy-3-iodo-phenoxy)-3-iodo-phenyl]propionic acid
(2S)-2-azanyl-3-[4-(4-hydroxy-3-iodo-phenoxy)-3-iodo-phenyl]propanoic acid | [EINECS(EC#)]
225-005-7 | [Molecular Formula]
C15H13I2NO4 | [MDL Number]
MFCD01863378 | [MOL File]
4604-41-5.mol | [Molecular Weight]
525.077 |
| Chemical Properties | Back Directory | [Appearance]
Off-White Powder | [Melting point ]
178-180°C | [Boiling point ]
520.7±50.0 °C(Predicted) | [density ]
2.095±0.06 g/cm3(Predicted) | [storage temp. ]
Amber Vial, -20°C Freezer, Under Inert Atmosphere | [solubility ]
Aqueous Base (Slightly) | [form ]
Solid | [pka]
2.17±0.20(Predicted) | [color ]
Off-White to Beige | [Stability:]
Light Sensitive | [InChI]
InChI=1S/C15H13I2NO4/c16-10-7-9(2-3-13(10)19)22-14-4-1-8(5-11(14)17)6-12(18)15(20)21/h1-5,7,12,19H,6,18H2,(H,20,21)/t12-/m0/s1 | [InChIKey]
CPCJBZABTUOGNM-LBPRGKRZSA-N | [SMILES]
C(O)(=O)[C@H](CC1=CC=C(OC2=CC=C(O)C(I)=C2)C(I)=C1)N |
| Hazard Information | Back Directory | [Chemical Properties]
Off-White Powder | [Uses]
Of interest for the early detection and treatment of congenital or drug-induced hypothyroidism in the developing human fetus | [Description]
3,3''-Diiodo-L-thyronine is a metabolite of thyroid hormone that is also known as T2 or 3,3’-T2.1 It is derived enzymatically from triiodothyronine isoforms T3 and reverse T3. T2 and its analog 3,5-T2 stimulate the activity of cytochrome c oxidase by blocking inhibition by ATP.2,3 | [Definition]
ChEBI: 3,3'-diiodo-L-thyronine is a 3,3'-diiodothyronine. It has a role as a human metabolite. | [IC 50]
Human Endogenous Metabolite; COX | [References]
[1] G PINNA. 3,3’-Diiodothyronine concentrations in the sera of patients with nonthyroidal illnesses and brain tumors and of healthy subjects during acute stress.[J]. Journal of Clinical Endocrinology & Metabolism, 1998, 83 9: 3071-3077. DOI: 10.1210/jcem.83.9.5080
[2] F. GOGLIA . Interaction of diiodothyronines with isolated cytochromec oxidase[J]. FEBS Letters, 1994, 346 2: Pages 295-298. DOI: 10.1016/0014-5793(94)00476-5
[3] S ARNOLD B K F Goglia. 3,5-Diiodothyronine binds to subunit Va of cytochrome-c oxidase and abolishes the allosteric inhibition of respiration by ATP.[J]. European journal of biochemistry, 1998, 252 2: 325-330. DOI: 10.1046/j.1432-1327.1998.2520325.x |
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